Abstract
2 siblings with Fanconi's anemia, 1 male and 1 female, aged 22 and 24 years, respectively, were evaluated at the Johns Hopkins Hospital because of short stature and hypogonadism. Plasma levels of somatomedin-C were normal in both patients, suggesting that the production of biologically active growth hormone was normal in these subjects. In addition, measurements of serum gonadotropins and plasma androgens in our patients, along with data accumulated from previous studies in the literature, show that abnormal sexual development in patients with Fanconi's anemia is due to hypergonadotropic hypogonadism.
| Original language | English |
|---|---|
| Pages (from-to) | 137-141 |
| Number of pages | 5 |
| Journal | Hormone Research |
| Volume | 19 |
| Issue number | 3 |
| State | Published - Jan 1 1984 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Endocrinology
Cite this
Gonadal function in two Siblings with Fanconi's anemia. / Berkovitz, Gary; Zinkham, W. H.; Migeon, C. J.
In: Hormone Research, Vol. 19, No. 3, 01.01.1984, p. 137-141.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gonadal function in two Siblings with Fanconi's anemia
AU - Berkovitz, Gary
AU - Zinkham, W. H.
AU - Migeon, C. J.
PY - 1984/1/1
Y1 - 1984/1/1
N2 - 2 siblings with Fanconi's anemia, 1 male and 1 female, aged 22 and 24 years, respectively, were evaluated at the Johns Hopkins Hospital because of short stature and hypogonadism. Plasma levels of somatomedin-C were normal in both patients, suggesting that the production of biologically active growth hormone was normal in these subjects. In addition, measurements of serum gonadotropins and plasma androgens in our patients, along with data accumulated from previous studies in the literature, show that abnormal sexual development in patients with Fanconi's anemia is due to hypergonadotropic hypogonadism.
AB - 2 siblings with Fanconi's anemia, 1 male and 1 female, aged 22 and 24 years, respectively, were evaluated at the Johns Hopkins Hospital because of short stature and hypogonadism. Plasma levels of somatomedin-C were normal in both patients, suggesting that the production of biologically active growth hormone was normal in these subjects. In addition, measurements of serum gonadotropins and plasma androgens in our patients, along with data accumulated from previous studies in the literature, show that abnormal sexual development in patients with Fanconi's anemia is due to hypergonadotropic hypogonadism.
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UR - http://www.scopus.com/inward/citedby.url?scp=0021357486&partnerID=8YFLogxK
M3 - Article
C2 - 6538869
AN - SCOPUS:0021357486
VL - 19
SP - 137
EP - 141
JO - Hormone Research in Paediatrics
JF - Hormone Research in Paediatrics
SN - 1663-2818
IS - 3
ER -