Gonadal function in two Siblings with Fanconi's anemia

G. D. Berkovitz; W. H. Zinkham; C. J. Migeon

doi:10.1159/000179880

Gonadal function in two Siblings with Fanconi's anemia

G. D. Berkovitz, W. H. Zinkham, C. J. Migeon

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

2 siblings with Fanconi's anemia, 1 male and 1 female, aged 22 and 24 years, respectively, were evaluated at the Johns Hopkins Hospital because of short stature and hypogonadism. Plasma levels of somatomedin-C were normal in both patients, suggesting that the production of biologically active growth hormone was normal in these subjects. In addition, measurements of serum gonadotropins and plasma androgens in our patients, along with data accumulated from previous studies in the literature, show that abnormal sexual development in patients with Fanconi's anemia is due to hypergonadotropic hypogonadism.

Original language	English (US)
Pages (from-to)	137-141
Number of pages	5
Journal	Hormone Research
Volume	19
Issue number	3
DOIs	https://doi.org/10.1159/000179880
State	Published - 1984
Externally published	Yes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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author = "Berkovitz, {G. D.} and Zinkham, {W. H.} and Migeon, {C. J.}",

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AU - Zinkham, W. H.

AU - Migeon, C. J.

PY - 1984

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N2 - 2 siblings with Fanconi's anemia, 1 male and 1 female, aged 22 and 24 years, respectively, were evaluated at the Johns Hopkins Hospital because of short stature and hypogonadism. Plasma levels of somatomedin-C were normal in both patients, suggesting that the production of biologically active growth hormone was normal in these subjects. In addition, measurements of serum gonadotropins and plasma androgens in our patients, along with data accumulated from previous studies in the literature, show that abnormal sexual development in patients with Fanconi's anemia is due to hypergonadotropic hypogonadism.

AB - 2 siblings with Fanconi's anemia, 1 male and 1 female, aged 22 and 24 years, respectively, were evaluated at the Johns Hopkins Hospital because of short stature and hypogonadism. Plasma levels of somatomedin-C were normal in both patients, suggesting that the production of biologically active growth hormone was normal in these subjects. In addition, measurements of serum gonadotropins and plasma androgens in our patients, along with data accumulated from previous studies in the literature, show that abnormal sexual development in patients with Fanconi's anemia is due to hypergonadotropic hypogonadism.

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Gonadal function in two Siblings with Fanconi's anemia

Abstract

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