Gold nanoparticles inhibit VEGF165-induced proliferation of HUVEC cells

R. Bhattacharya, P. Mukherjee, Z. Xiong, A. Atala, S. Soker, D. Mukhopadhyay

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

Gold nanoparticles inhibit VEGF165, a heparin binding growth factor, induced proliferation of HUVEC cells but do not interfere with the activity of VEGF121, a non-heparin binding growth factor. The interaction between gold nanoparticles and VEGF165 primarily occurs through the heparin binding domain of the protein. VEGF121 does not have a heparin binding domain and hence is not inactivated by gold nanoparticles.

Original languageEnglish
Pages (from-to)2479-2481
Number of pages3
JournalNano Letters
Volume4
Issue number12
DOIs
StatePublished - Dec 1 2004
Externally publishedYes

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heparins
Gold
Heparin
gold
Nanoparticles
nanoparticles
Intercellular Signaling Peptides and Proteins
cells
Proteins
proteins
interactions

ASJC Scopus subject areas

  • Materials Science(all)
  • Electronic, Optical and Magnetic Materials
  • Chemistry (miscellaneous)

Cite this

Bhattacharya, R., Mukherjee, P., Xiong, Z., Atala, A., Soker, S., & Mukhopadhyay, D. (2004). Gold nanoparticles inhibit VEGF165-induced proliferation of HUVEC cells. Nano Letters, 4(12), 2479-2481. https://doi.org/10.1021/nl0483789

Gold nanoparticles inhibit VEGF165-induced proliferation of HUVEC cells. / Bhattacharya, R.; Mukherjee, P.; Xiong, Z.; Atala, A.; Soker, S.; Mukhopadhyay, D.

In: Nano Letters, Vol. 4, No. 12, 01.12.2004, p. 2479-2481.

Research output: Contribution to journalArticle

Bhattacharya, R, Mukherjee, P, Xiong, Z, Atala, A, Soker, S & Mukhopadhyay, D 2004, 'Gold nanoparticles inhibit VEGF165-induced proliferation of HUVEC cells', Nano Letters, vol. 4, no. 12, pp. 2479-2481. https://doi.org/10.1021/nl0483789
Bhattacharya R, Mukherjee P, Xiong Z, Atala A, Soker S, Mukhopadhyay D. Gold nanoparticles inhibit VEGF165-induced proliferation of HUVEC cells. Nano Letters. 2004 Dec 1;4(12):2479-2481. https://doi.org/10.1021/nl0483789
Bhattacharya, R. ; Mukherjee, P. ; Xiong, Z. ; Atala, A. ; Soker, S. ; Mukhopadhyay, D. / Gold nanoparticles inhibit VEGF165-induced proliferation of HUVEC cells. In: Nano Letters. 2004 ; Vol. 4, No. 12. pp. 2479-2481.
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