GNAQ/11 mutations in uveal melanoma: Is YAP the key to targeted therapy?

Matthew G. Field, J. William Harbour

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

GNAQ and GNA11 are frequently mutated in uveal melanoma, but they remain difficult therapeutic targets. In this issue of Cancer Cell, Feng and colleagues and Yu and colleagues demonstrate that the oncogenic activity of mutant GNAQ/11 is mediated at least in part through YAP, potentially uncovering a new therapeutic strategy.

Original languageEnglish
Pages (from-to)714-715
Number of pages2
JournalCancer Cell
Volume25
Issue number6
DOIs
StatePublished - Jun 16 2014

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Mutation
Therapeutics
Neoplasms
Uveal melanoma

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Oncology

Cite this

GNAQ/11 mutations in uveal melanoma : Is YAP the key to targeted therapy? / Field, Matthew G.; William Harbour, J.

In: Cancer Cell, Vol. 25, No. 6, 16.06.2014, p. 714-715.

Research output: Contribution to journalArticle

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