GNAQ/11 mutations in uveal melanoma: Is YAP the key to targeted therapy?

Matthew G. Field, J. William Harbour

Research output: Contribution to journalShort survey

21 Scopus citations

Abstract

GNAQ and GNA11 are frequently mutated in uveal melanoma, but they remain difficult therapeutic targets. In this issue of Cancer Cell, Feng and colleagues and Yu and colleagues demonstrate that the oncogenic activity of mutant GNAQ/11 is mediated at least in part through YAP, potentially uncovering a new therapeutic strategy.

Original languageEnglish (US)
Pages (from-to)714-715
Number of pages2
JournalCancer Cell
Volume25
Issue number6
DOIs
StatePublished - Jun 16 2014

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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