Glycoprotein gene sequence variation in rhesus monkey rhadinovirus

Young C. Shin, Leandro R. Jones, Julieta Manrique, William Lauer, Angela Carville, Keith G. Mansfield, Ronald C. Desrosiers

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Gene sequences for seven glycoproteins from 20 independent isolates of rhesus monkey rhadinovirus (RRV) and of the corresponding seven glycoprotein genes from nine strains of the Kaposi's sarcoma-associated herpesvirus (KSHV) were obtained and analyzed. Phylogenetic analysis revealed two discrete groupings of RRV gH sequences, two discrete groupings of RRV gL sequences and two discrete groupings of RRV gB sequences. We called these phylogenetic groupings gHa, gHb, gLa, gLb, gBa and gBb. gHa was always paired with gLa and gHb was always paired with gLb for any individual RRV isolate. Since gH and gL are known to be interacting partners, these results suggest the need of matching sequence types for function of these cooperating proteins. gB phylogenetic grouping was not associated with gH/gL phylogenetic grouping. Our results demonstrate two distinct, distantly-related phylogenetic groupings of gH and gL of RRV despite a remarkable degree of sequence conservation within each individual phylogenetic group.

Original languageEnglish (US)
Pages (from-to)175-186
Number of pages12
JournalVirology
Volume400
Issue number2
DOIs
StatePublished - May 2010

Keywords

  • Phylogenetic grouping
  • RRV glycoprotein
  • Variation

ASJC Scopus subject areas

  • Virology

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  • Cite this

    Shin, Y. C., Jones, L. R., Manrique, J., Lauer, W., Carville, A., Mansfield, K. G., & Desrosiers, R. C. (2010). Glycoprotein gene sequence variation in rhesus monkey rhadinovirus. Virology, 400(2), 175-186. https://doi.org/10.1016/j.virol.2010.01.030