Glycolytic and oxidative metabolic contributions to potassium ion transport in rat cerebral cortex

M. Rosenthal, Thomas Sick

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Putative roles of glycolytic and oxidative metabolism in the removal of potassium ion from the extracellular space were examined in rat cerebral cortex. In response to direct electrical stimulation of the cerebral surface, the activity of extracellular potassium ion (K(o)+) transiently increased. Inhibition of glycolysis with iodoacetate prolonged the time required for dissipation of the elevated K(o)+. This slowing was most evident in the early period after stimulation, when K(o)+ was relatively high. Levels of high-energy intermediates were unchanged by iodoacetate. In contrast, severe hypoxemia was without effect during the early phase of K+ removal but hypoxemia slowed the later restoration of the K(o)+ baseline. These data demonstrate that the rapid removal of potassium ion from the extracellular space following intense neuronal activity is aided by the Embden-Myerhoff metabolic pathways and perhaps by direct coupling of ATP produced by glycolysis. We suggest that removal of potassium ion from the brain extracellular space depends on two ATP pools, one derived from oxidative phosphorylation, the other from glycolysis. The glycolytic ATP pool may be most involved in the early and rapid phase of potassium clearance, the oxidative ATP pool may be more associated with the second and slower phase of K(o)+ clearance. and with the maintenance of the K(o)+ baseline under 'resting' conditions.

Original languageEnglish
JournalCanadian Journal of Physiology and Pharmacology
Volume70
Issue numberSUPPL.
StatePublished - Dec 1 1992

Fingerprint

Ion Transport
Cerebral Cortex
Potassium
Extracellular Space
Glycolysis
Adenosine Triphosphate
Ions
Iodoacetates
Oxidative Phosphorylation
Metabolic Networks and Pathways
Electric Stimulation
Maintenance
Brain
Hypoxia

Keywords

  • glycolysis
  • hypoxemia
  • iodoacetate
  • oxidative phosphorylation
  • potassium

ASJC Scopus subject areas

  • Physiology
  • Pharmacology

Cite this

Glycolytic and oxidative metabolic contributions to potassium ion transport in rat cerebral cortex. / Rosenthal, M.; Sick, Thomas.

In: Canadian Journal of Physiology and Pharmacology, Vol. 70, No. SUPPL., 01.12.1992.

Research output: Contribution to journalArticle

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