Glycolysis, oxidative metabolism, and brain potassium ion clearance

Cesar N. Raffin, Myron Rosenthal, Raul Busto, Thomas Sick

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Studies were directed toward defining relationships between brain ion transport, glycolysis, and oxidative phosphorylation. This was done by examining the relative sensitivity to hypoxemia and to iodoacetate (lAA)-induced inhibition of glycolysis in rats anesthetized with pentobarbital. Both insults had minimal effects on Ko+ baseline. In response to neuronal activation, IAA increased the time required for Ko+ clearance from maximal values to half-recovery of baseline. Hypoxemia slowed the later phase of Ko+ clearance, when Ko+ was approaching "resting" levels. Hypoxemia produced greater declines in high-energy intermediates than did IAA, which indicated that the IAA effect was not due to a greater overall insult to metabolism and suggested a direct link between ATP produced by glycolysis and ion transport activity. These data demonstrate that Ko+ clearance requires energy from glycolysis and oxidative phosphorylation for different phases of the recovery process and that inhibition specific to glycolysis or oxidative phosphorylation may be temporally resolved within a single stimulus.

Original languageEnglish
Pages (from-to)34-42
Number of pages9
JournalJournal of Cerebral Blood Flow and Metabolism
Volume12
Issue number1
StatePublished - Dec 1 1992

Fingerprint

Glycolysis
Potassium
Ions
Oxidative Phosphorylation
Brain
Ion Transport
Iodoacetates
Pentobarbital
Adenosine Triphosphate
Hypoxia

Keywords

  • Brain
  • Glycolysis
  • Hypoxia
  • Ion transport hypoxemia
  • Potassium

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)
  • Endocrinology, Diabetes and Metabolism

Cite this

Raffin, C. N., Rosenthal, M., Busto, R., & Sick, T. (1992). Glycolysis, oxidative metabolism, and brain potassium ion clearance. Journal of Cerebral Blood Flow and Metabolism, 12(1), 34-42.

Glycolysis, oxidative metabolism, and brain potassium ion clearance. / Raffin, Cesar N.; Rosenthal, Myron; Busto, Raul; Sick, Thomas.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 12, No. 1, 01.12.1992, p. 34-42.

Research output: Contribution to journalArticle

Raffin, CN, Rosenthal, M, Busto, R & Sick, T 1992, 'Glycolysis, oxidative metabolism, and brain potassium ion clearance', Journal of Cerebral Blood Flow and Metabolism, vol. 12, no. 1, pp. 34-42.
Raffin, Cesar N. ; Rosenthal, Myron ; Busto, Raul ; Sick, Thomas. / Glycolysis, oxidative metabolism, and brain potassium ion clearance. In: Journal of Cerebral Blood Flow and Metabolism. 1992 ; Vol. 12, No. 1. pp. 34-42.
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