Glycation and diabetes: The RAGE connection

Barry Hudson, Marion A. Hofmann, Loredana Bucciarelli, Thoralf Wendt, Bernhard Moser, Yan Lu, Wu Qu, David M. Stern, Vivette D'Agati, Shi Du Yan, Shi Fang Yan, Peter J. Grant, Ann Marie Schmidt

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The hyperglycaemic state seen in diabetes mellitus is associated with the development of diabetes-specific microvascular complications and accelerated macrovascular disease. Evidence implicates the formation and subsequent effects of advanced glycation end-products (AGEs) as a contributing cause. AGEs exert their effects through interaction with the Receptor for AGE (RAGE) which upregulates expression of the receptor and induces a cascade of cytotoxic pathways. Accumulation of AGE/RAGE can be seen at sites of vascular disease in both animal models of diabetes and human diabetic subjects. Blockade of RAGE in animal models of diabetes suppresses development of dysfunction in the vasculature and atherosclerosis development. Genetic studies of RAGE reveal that a number of allelic variants of RAGE occur in key protein and regulatory domains. A Gly to Ser change at position 82 and two 5′ flanking polymorphisms at position -374 and -429 lead to altered function and expression of RAGE which may impact on diabetic vascular disease development. Therapy aimed to block RAGE upregulation may prove to be useful in treating individuals with diabetic vascular disease.

Original languageEnglish
Pages (from-to)1515-1521
Number of pages7
JournalCurrent Science
Volume83
Issue number12
StatePublished - Dec 25 2002
Externally publishedYes

Fingerprint

glycation
diabetes
receptors
vascular diseases
Diabetic Angiopathies
Advanced Glycosylation End Products
Up-Regulation
Animal Models
animal models
Advanced Glycosylation End Product-Specific Receptor
disease models
Vascular Diseases
diabetes mellitus
atherosclerosis
Atherosclerosis
polymorphism
Diabetes Mellitus
therapeutics
advanced glycation end products

ASJC Scopus subject areas

  • General
  • Agricultural and Biological Sciences(all)

Cite this

Hudson, B., Hofmann, M. A., Bucciarelli, L., Wendt, T., Moser, B., Lu, Y., ... Schmidt, A. M. (2002). Glycation and diabetes: The RAGE connection. Current Science, 83(12), 1515-1521.

Glycation and diabetes : The RAGE connection. / Hudson, Barry; Hofmann, Marion A.; Bucciarelli, Loredana; Wendt, Thoralf; Moser, Bernhard; Lu, Yan; Qu, Wu; Stern, David M.; D'Agati, Vivette; Yan, Shi Du; Yan, Shi Fang; Grant, Peter J.; Schmidt, Ann Marie.

In: Current Science, Vol. 83, No. 12, 25.12.2002, p. 1515-1521.

Research output: Contribution to journalArticle

Hudson, B, Hofmann, MA, Bucciarelli, L, Wendt, T, Moser, B, Lu, Y, Qu, W, Stern, DM, D'Agati, V, Yan, SD, Yan, SF, Grant, PJ & Schmidt, AM 2002, 'Glycation and diabetes: The RAGE connection', Current Science, vol. 83, no. 12, pp. 1515-1521.
Hudson B, Hofmann MA, Bucciarelli L, Wendt T, Moser B, Lu Y et al. Glycation and diabetes: The RAGE connection. Current Science. 2002 Dec 25;83(12):1515-1521.
Hudson, Barry ; Hofmann, Marion A. ; Bucciarelli, Loredana ; Wendt, Thoralf ; Moser, Bernhard ; Lu, Yan ; Qu, Wu ; Stern, David M. ; D'Agati, Vivette ; Yan, Shi Du ; Yan, Shi Fang ; Grant, Peter J. ; Schmidt, Ann Marie. / Glycation and diabetes : The RAGE connection. In: Current Science. 2002 ; Vol. 83, No. 12. pp. 1515-1521.
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