Gluteus maximus and soleus compensate for simulated quadriceps atrophy and activation failure during walking

Julie A. Thompson, Ajit M.W. Chaudhari, Laura C. Schmitt, Thomas Best, Robert A. Siston

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Important activities of daily living, like walking and stair climbing, may be impaired by muscle weakness. In particular, quadriceps weakness is common in populations such as those with knee osteoarthritis (OA) and following ACL injury and may be a result of muscle atrophy or reduced voluntary muscle activation. While weak quadriceps have been strongly correlated with functional limitations in these populations, the important cause-effect relationships between abnormal lower extremity muscle function and patient function remain unknown. As a first step towards determining those relationships, the purpose of this study was to estimate changes in muscle forces and contributions to support and progression to maintain normal gait in response to two sources of quadriceps weakness: atrophy and activation failure. We used muscle-driven simulations to track normal gait kinematics in healthy subjects and applied simulated quadriceps weakness as atrophy and activation failure to evaluate compensation patterns associated with the individual sources of weakness. We found that the gluteus maximus and soleus muscles display the greatest ability to compensate for simulated quadriceps weakness. Also, by simulating two different causes of muscle weakness, this model suggested different compensation strategies by the lower extremity musculature in response to atrophy and activation deficits. Estimating the compensation strategies that are necessary to maintain normal gait will enable investigations of the role of muscle weakness in abnormal gait and inform potential rehabilitation strategies to improve such conditions.

Original languageEnglish (US)
Pages (from-to)2165-2172
Number of pages8
JournalJournal of Biomechanics
Volume46
Issue number13
DOIs
StatePublished - Sep 3 2013
Externally publishedYes

Fingerprint

Gait
Walking
Atrophy
Muscle
Muscle Weakness
Chemical activation
Muscles
Lower Extremity
Skeletal Muscle
Muscular Atrophy
Knee Osteoarthritis
Activities of Daily Living
Biomechanical Phenomena
Population
Healthy Volunteers
Rehabilitation
Stairs
Patient rehabilitation
Kinematics

Keywords

  • Gait
  • Muscle-driven simulation
  • Quadriceps weakness

ASJC Scopus subject areas

  • Biophysics
  • Orthopedics and Sports Medicine
  • Biomedical Engineering
  • Rehabilitation

Cite this

Gluteus maximus and soleus compensate for simulated quadriceps atrophy and activation failure during walking. / Thompson, Julie A.; Chaudhari, Ajit M.W.; Schmitt, Laura C.; Best, Thomas; Siston, Robert A.

In: Journal of Biomechanics, Vol. 46, No. 13, 03.09.2013, p. 2165-2172.

Research output: Contribution to journalArticle

Thompson, Julie A. ; Chaudhari, Ajit M.W. ; Schmitt, Laura C. ; Best, Thomas ; Siston, Robert A. / Gluteus maximus and soleus compensate for simulated quadriceps atrophy and activation failure during walking. In: Journal of Biomechanics. 2013 ; Vol. 46, No. 13. pp. 2165-2172.
@article{d4eb14b165db4032aab09a61ec01c6c7,
title = "Gluteus maximus and soleus compensate for simulated quadriceps atrophy and activation failure during walking",
abstract = "Important activities of daily living, like walking and stair climbing, may be impaired by muscle weakness. In particular, quadriceps weakness is common in populations such as those with knee osteoarthritis (OA) and following ACL injury and may be a result of muscle atrophy or reduced voluntary muscle activation. While weak quadriceps have been strongly correlated with functional limitations in these populations, the important cause-effect relationships between abnormal lower extremity muscle function and patient function remain unknown. As a first step towards determining those relationships, the purpose of this study was to estimate changes in muscle forces and contributions to support and progression to maintain normal gait in response to two sources of quadriceps weakness: atrophy and activation failure. We used muscle-driven simulations to track normal gait kinematics in healthy subjects and applied simulated quadriceps weakness as atrophy and activation failure to evaluate compensation patterns associated with the individual sources of weakness. We found that the gluteus maximus and soleus muscles display the greatest ability to compensate for simulated quadriceps weakness. Also, by simulating two different causes of muscle weakness, this model suggested different compensation strategies by the lower extremity musculature in response to atrophy and activation deficits. Estimating the compensation strategies that are necessary to maintain normal gait will enable investigations of the role of muscle weakness in abnormal gait and inform potential rehabilitation strategies to improve such conditions.",
keywords = "Gait, Muscle-driven simulation, Quadriceps weakness",
author = "Thompson, {Julie A.} and Chaudhari, {Ajit M.W.} and Schmitt, {Laura C.} and Thomas Best and Siston, {Robert A.}",
year = "2013",
month = "9",
day = "3",
doi = "10.1016/j.jbiomech.2013.06.033",
language = "English (US)",
volume = "46",
pages = "2165--2172",
journal = "Journal of Biomechanics",
issn = "0021-9290",
publisher = "Elsevier Limited",
number = "13",

}

TY - JOUR

T1 - Gluteus maximus and soleus compensate for simulated quadriceps atrophy and activation failure during walking

AU - Thompson, Julie A.

AU - Chaudhari, Ajit M.W.

AU - Schmitt, Laura C.

AU - Best, Thomas

AU - Siston, Robert A.

PY - 2013/9/3

Y1 - 2013/9/3

N2 - Important activities of daily living, like walking and stair climbing, may be impaired by muscle weakness. In particular, quadriceps weakness is common in populations such as those with knee osteoarthritis (OA) and following ACL injury and may be a result of muscle atrophy or reduced voluntary muscle activation. While weak quadriceps have been strongly correlated with functional limitations in these populations, the important cause-effect relationships between abnormal lower extremity muscle function and patient function remain unknown. As a first step towards determining those relationships, the purpose of this study was to estimate changes in muscle forces and contributions to support and progression to maintain normal gait in response to two sources of quadriceps weakness: atrophy and activation failure. We used muscle-driven simulations to track normal gait kinematics in healthy subjects and applied simulated quadriceps weakness as atrophy and activation failure to evaluate compensation patterns associated with the individual sources of weakness. We found that the gluteus maximus and soleus muscles display the greatest ability to compensate for simulated quadriceps weakness. Also, by simulating two different causes of muscle weakness, this model suggested different compensation strategies by the lower extremity musculature in response to atrophy and activation deficits. Estimating the compensation strategies that are necessary to maintain normal gait will enable investigations of the role of muscle weakness in abnormal gait and inform potential rehabilitation strategies to improve such conditions.

AB - Important activities of daily living, like walking and stair climbing, may be impaired by muscle weakness. In particular, quadriceps weakness is common in populations such as those with knee osteoarthritis (OA) and following ACL injury and may be a result of muscle atrophy or reduced voluntary muscle activation. While weak quadriceps have been strongly correlated with functional limitations in these populations, the important cause-effect relationships between abnormal lower extremity muscle function and patient function remain unknown. As a first step towards determining those relationships, the purpose of this study was to estimate changes in muscle forces and contributions to support and progression to maintain normal gait in response to two sources of quadriceps weakness: atrophy and activation failure. We used muscle-driven simulations to track normal gait kinematics in healthy subjects and applied simulated quadriceps weakness as atrophy and activation failure to evaluate compensation patterns associated with the individual sources of weakness. We found that the gluteus maximus and soleus muscles display the greatest ability to compensate for simulated quadriceps weakness. Also, by simulating two different causes of muscle weakness, this model suggested different compensation strategies by the lower extremity musculature in response to atrophy and activation deficits. Estimating the compensation strategies that are necessary to maintain normal gait will enable investigations of the role of muscle weakness in abnormal gait and inform potential rehabilitation strategies to improve such conditions.

KW - Gait

KW - Muscle-driven simulation

KW - Quadriceps weakness

UR - http://www.scopus.com/inward/record.url?scp=84882242911&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882242911&partnerID=8YFLogxK

U2 - 10.1016/j.jbiomech.2013.06.033

DO - 10.1016/j.jbiomech.2013.06.033

M3 - Article

VL - 46

SP - 2165

EP - 2172

JO - Journal of Biomechanics

JF - Journal of Biomechanics

SN - 0021-9290

IS - 13

ER -