Glutathione depletion following inhalation anesthesia

M. A. Zumbiel, V. Fiserova-Bergerova, Theodore Malinin, D. A. Holaday

Research output: Contribution to journalArticle

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Abstract

Glutathione depletion following inhalation of halogenated anesthetics was investigated as a possible mechanism of toxic reactions associated with anesthesia. Concentrations of reduced glutathione were measured in the blood, liver, lung and kidney of the mouse after anesthesia with enflurane, fluroxene, halothane, isoflurane, methoxyflurane, or trichloroethylene. The anesthetic had no effect on glutathione concentrations in tissue except when fluroxene was used. After two hours of fluroxene anesthesia, glutathione in liver, lung, kidney, and blood was depleted by 93, 85, 85, and 61 per cent, respectively. The depletion was dose-dependent and was more extensive in animals anesthetized after phenobarbital pretreatment. Glutathione was also depleted in livers and lungs of rats anesthetized with fluroxene (60 and 38 per cent, respectively). In blood of rhesus monkeys anesthetized with fluroxene, glutathione was depleted by only 13 per cent. Extents of glutathione depletion are related to fluroxene toxicities in the three species studied.

Original languageEnglish
Pages (from-to)102-108
Number of pages7
JournalAnesthesiology
Volume49
Issue number2
StatePublished - Dec 1 1978

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Inhalation Anesthesia
Glutathione
Anesthesia
Lung
Liver
Methoxyflurane
Inhalation Anesthetics
Kidney
Trichloroethylene
Enflurane
Poisons
Isoflurane
Halothane
Phenobarbital
Macaca mulatta
Anesthetics
fluroxene

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Zumbiel, M. A., Fiserova-Bergerova, V., Malinin, T., & Holaday, D. A. (1978). Glutathione depletion following inhalation anesthesia. Anesthesiology, 49(2), 102-108.

Glutathione depletion following inhalation anesthesia. / Zumbiel, M. A.; Fiserova-Bergerova, V.; Malinin, Theodore; Holaday, D. A.

In: Anesthesiology, Vol. 49, No. 2, 01.12.1978, p. 102-108.

Research output: Contribution to journalArticle

Zumbiel, MA, Fiserova-Bergerova, V, Malinin, T & Holaday, DA 1978, 'Glutathione depletion following inhalation anesthesia', Anesthesiology, vol. 49, no. 2, pp. 102-108.
Zumbiel MA, Fiserova-Bergerova V, Malinin T, Holaday DA. Glutathione depletion following inhalation anesthesia. Anesthesiology. 1978 Dec 1;49(2):102-108.
Zumbiel, M. A. ; Fiserova-Bergerova, V. ; Malinin, Theodore ; Holaday, D. A. / Glutathione depletion following inhalation anesthesia. In: Anesthesiology. 1978 ; Vol. 49, No. 2. pp. 102-108.
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