Glutathione Conformations and Its Implications for in vivo Magnetic Resonance Spectroscopy

Pravat K. Mandal, Deepika Shukla, Varan Govind, Yves Boulard, Lars Ersland

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Glutathione (GSH) is a major antioxidant in humans that is involved in the detoxification of reactive radicals and peroxides. The molecular structural conformations of GSH depend on the surrounding micro-environment, and it has been experimentally evaluated using NMR and Raman spectroscopic techniques as well as by molecular dynamics simulation studies. The converging report indicates that GSH exists mainly in two major conformations, i.e., "extended" and "folded". The NMR-derived information on the GSH conformers is essential to obtain optimal acquisition parameters in in vivo MRS experiments targeted for GSH detection. To further investigate the implications of GSH conformers in in vivo MRS studies and their relative proportions in healthy and pathological conditions, a multi-center clinical research study is necessary with a common protocol for GSH detection and quantification.

Original languageEnglish (US)
Pages (from-to)537-541
Number of pages5
JournalJournal of Alzheimer's Disease
Volume59
Issue number2
DOIs
StatePublished - 2017

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Keywords

  • Antioxidant
  • brain
  • conformation
  • glutathione
  • magnetic resonance spectroscopy
  • molecular dynamics
  • nuclear magnetic resonance

ASJC Scopus subject areas

  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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