Glutamine synthetase: Glial localization in brain

Antonio Martinez-Hernandez, Katherine P. Bell, Michael D. Norenberg

Research output: Contribution to journalArticlepeer-review

954 Scopus citations


Light microscopy immunohistochemical techniques were used to examine the distribution of glutamine synthetase in rat brain. Glutamine synthetase was found to be localized in the glial cells. Neuronal cell bodies, endothelial cells, and choroid epithelium contained no enzyme. The findings indicate that glia have a crucial role in glutamic acid, γ-aminobutyric acid, and ammonia metabolism in brain. ANTONIO MARTINEZ-HERNANDEZ.

Original languageEnglish (US)
Pages (from-to)1356-1358
Number of pages3
Issue number4284
StatePublished - 1977
Externally publishedYes

ASJC Scopus subject areas

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