Glutamine synthetase: Glial localization in brain

Antonio Martinez-Hernandez; Katherine P. Bell; Michael D. Norenberg

doi:10.1126/science.14400

Glutamine synthetase: Glial localization in brain

Antonio Martinez-Hernandez, Katherine P. Bell, Michael D. Norenberg

Research output: Contribution to journal › Article › peer-review

935 Scopus citations

Abstract

Light microscopy immunohistochemical techniques were used to examine the distribution of glutamine synthetase in rat brain. Glutamine synthetase was found to be localized in the glial cells. Neuronal cell bodies, endothelial cells, and choroid epithelium contained no enzyme. The findings indicate that glia have a crucial role in glutamic acid, γ-aminobutyric acid, and ammonia metabolism in brain. ANTONIO MARTINEZ-HERNANDEZ.

Original language	English (US)
Pages (from-to)	1356-1358
Number of pages	3
Journal	Science
Volume	195
Issue number	4284
DOIs	https://doi.org/10.1126/science.14400
State	Published - 1977
Externally published	Yes

ASJC Scopus subject areas

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title = "Glutamine synthetase: Glial localization in brain",

abstract = "Light microscopy immunohistochemical techniques were used to examine the distribution of glutamine synthetase in rat brain. Glutamine synthetase was found to be localized in the glial cells. Neuronal cell bodies, endothelial cells, and choroid epithelium contained no enzyme. The findings indicate that glia have a crucial role in glutamic acid, γ-aminobutyric acid, and ammonia metabolism in brain. ANTONIO MARTINEZ-HERNANDEZ.",

author = "Antonio Martinez-Hernandez and Bell, {Katherine P.} and Norenberg, {Michael D.}",

year = "1977",

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AB - Light microscopy immunohistochemical techniques were used to examine the distribution of glutamine synthetase in rat brain. Glutamine synthetase was found to be localized in the glial cells. Neuronal cell bodies, endothelial cells, and choroid epithelium contained no enzyme. The findings indicate that glia have a crucial role in glutamic acid, γ-aminobutyric acid, and ammonia metabolism in brain. ANTONIO MARTINEZ-HERNANDEZ.

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