Glutamate transporters: Using fluorescence to determine structure and to detect conformational changes

H. Peter Larsson; Hans P. Koch

Glutamate transporters: Using fluorescence to determine structure and to detect conformational changes

Research output: Contribution to journal › Article › peer-review

Abstract

Glutamate transporters remove glutamate from the synapse, thereby recycling synaptiallyc released glutamate and maintaining a low extracellular concentration of glutamate. The molecular mechanism underlying glutamate uptake is not understood. We have used fluorescence techniques on human glutamate transporters in order to draw conclusions about the molecular mechanism of glutamate uptake.

Original language	English (US)
Pages (from-to)	21-24
Number of pages	4
Journal	Acta Biomedica de l'Ateneo Parmense
Volume	77
Issue number	SUPPL. 3
State	Published - Dec 12 2006
Externally published	Yes

Keywords

EAAT3
FRET
Sodium binding
VCF

ASJC Scopus subject areas

Medicine(all)

Cite this

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title = "Glutamate transporters: Using fluorescence to determine structure and to detect conformational changes",

abstract = "Glutamate transporters remove glutamate from the synapse, thereby recycling synaptiallyc released glutamate and maintaining a low extracellular concentration of glutamate. The molecular mechanism underlying glutamate uptake is not understood. We have used fluorescence techniques on human glutamate transporters in order to draw conclusions about the molecular mechanism of glutamate uptake.",

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AU - Larsson, H. Peter

AU - Koch, Hans P.

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N2 - Glutamate transporters remove glutamate from the synapse, thereby recycling synaptiallyc released glutamate and maintaining a low extracellular concentration of glutamate. The molecular mechanism underlying glutamate uptake is not understood. We have used fluorescence techniques on human glutamate transporters in order to draw conclusions about the molecular mechanism of glutamate uptake.

AB - Glutamate transporters remove glutamate from the synapse, thereby recycling synaptiallyc released glutamate and maintaining a low extracellular concentration of glutamate. The molecular mechanism underlying glutamate uptake is not understood. We have used fluorescence techniques on human glutamate transporters in order to draw conclusions about the molecular mechanism of glutamate uptake.

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KW - Sodium binding

KW - VCF

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Glutamate transporters: Using fluorescence to determine structure and to detect conformational changes

Abstract

Keywords

ASJC Scopus subject areas

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