Glutamate-induced cobalt uptake reveals non-NMDA receptors in developing rat taste buds

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6 Scopus citations


Non-NMDA type glutamate receptors are present in rat taste buds. However, the function of those receptors is not yet known. Developmental changes in the glutamate receptors in taste cells may provide clues to their functional role. We used a cobalt staining technique to determine at which stage in development functional non-NMDA glutamate receptors first appeared. Cobalt-stained taste bud cells first appeared in 20-day-old rats. The number of cobalt-stained cells increased with age and reached a maximum at 45 days. The shape of stained cells looked similar at all age groups. Cobalt-labeled cells appeared to be correlated with synaptic, not taste, glutamate receptors.

Original languageEnglish (US)
Pages (from-to)1715-1718
Number of pages4
Issue number8
StatePublished - Jun 13 2001


  • Development
  • Foliate papilla
  • Glutamate receptors
  • Taste bud
  • Tongue

ASJC Scopus subject areas

  • Neuroscience(all)


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