Glucose responsive hydrogel networks based on protein recognition

Jason D. Ehrick, Matthew R. Luckett, Santoshkumar Khatwani, Yinan Wei, Sapna K. Deo, Leonidas G. Bachas, Sylvia Daunert

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

Stimuli-responsive materials capable of manifesting physical changes in response to environmental signals are valuable tools for use in a variety of biomedical applications. Herein we describe one such smart glucose-responsive hydrogel material prepared by immobilizing the glucose/galactose binding protein within an acrylamide hydrogel network. This hydrogel demonstrates a quantitative "accordion"-like dynamic response in the presence of glucose. We further show the feasibility of employing this responsive smart material as a gating agent for controlled drug delivery, thus, demonstrating that these hydrogels may eventually lead to the development of implantable drug delivery systems for diabetes management applications. (Figure Presented)

Original languageEnglish (US)
Pages (from-to)864-868
Number of pages5
JournalMacromolecular Bioscience
Volume9
Issue number9
DOIs
StatePublished - Sep 9 2009
Externally publishedYes

Keywords

  • Biomaterials
  • Hydrogels
  • Proteins
  • Sensors
  • Swelling

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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