Glucose-oxidase based self-destructing polymeric vesicles

Alessandro Napoli, Mark J. Boerakker, Nicola Tirelli, Roeland J M Nolte, Nico A J M Sommerdijk, Jeffrey A. Hubbell

Research output: Contribution to journalArticle

183 Citations (Scopus)

Abstract

We have designed oxidation-responsive vesicles from synthetic amphiphilic block copolymers ("polymersomes") of ethylene glycol and propylene sulfide. Thioethers in the hydrophobic poly(propylene sulfide) block are converted into the more hydrophilic sulfoxides and sulfones upon exposure to an oxidatiye environment, changing the hydrophilic-lipophilic balance of the macroamphiphile and thus inducing its solubilization. Here we sought to explore generation of the oxidative environment and induction of polymersome destabilization through production of hydrogen peroxide by the glucose-oxidase (GOx)/glucose/oxygen system. We studied the encapsulation of GOx within polymersomes, its stability and activity, and glucose-triggered polymersome destabilization. Stimulus-responsive polymersomes may find applications as nanocontainers in sensing devices and as drug delivery systems.

Original languageEnglish
Pages (from-to)3487-3491
Number of pages5
JournalLangmuir
Volume20
Issue number9
DOIs
StatePublished - Apr 27 2004
Externally publishedYes

Fingerprint

Glucose Oxidase
Glucose oxidase
oxidase
glucose
Sulfoxides
Glucose
Sulfones
Ethylene Glycol
destabilization
Sulfides
Encapsulation
Hydrogen Peroxide
Block copolymers
sulfides
Oxygen
oxygen supply equipment
Ethylene glycol
Hydrogen peroxide
Oxidation
Propylene

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

Cite this

Napoli, A., Boerakker, M. J., Tirelli, N., Nolte, R. J. M., Sommerdijk, N. A. J. M., & Hubbell, J. A. (2004). Glucose-oxidase based self-destructing polymeric vesicles. Langmuir, 20(9), 3487-3491. https://doi.org/10.1021/la0357054

Glucose-oxidase based self-destructing polymeric vesicles. / Napoli, Alessandro; Boerakker, Mark J.; Tirelli, Nicola; Nolte, Roeland J M; Sommerdijk, Nico A J M; Hubbell, Jeffrey A.

In: Langmuir, Vol. 20, No. 9, 27.04.2004, p. 3487-3491.

Research output: Contribution to journalArticle

Napoli, A, Boerakker, MJ, Tirelli, N, Nolte, RJM, Sommerdijk, NAJM & Hubbell, JA 2004, 'Glucose-oxidase based self-destructing polymeric vesicles', Langmuir, vol. 20, no. 9, pp. 3487-3491. https://doi.org/10.1021/la0357054
Napoli A, Boerakker MJ, Tirelli N, Nolte RJM, Sommerdijk NAJM, Hubbell JA. Glucose-oxidase based self-destructing polymeric vesicles. Langmuir. 2004 Apr 27;20(9):3487-3491. https://doi.org/10.1021/la0357054
Napoli, Alessandro ; Boerakker, Mark J. ; Tirelli, Nicola ; Nolte, Roeland J M ; Sommerdijk, Nico A J M ; Hubbell, Jeffrey A. / Glucose-oxidase based self-destructing polymeric vesicles. In: Langmuir. 2004 ; Vol. 20, No. 9. pp. 3487-3491.
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