Glucosamine is a normal component of liver glycogen

Brent R. Kirkman, William J. Whelan

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

There have been several reports of the incorporation of glucosamine into liver glycogen by an intraperitoneal injection of galactosamine, but it has not previously been considered that glucosamine is a normal component of liver glycogen. We now report that glucosamine occurs endogenously in rabbit- and pig-liver glycogens in the amount of about 1 nmol per 10 mg glycogen. Like the glucosamine incorporated by exogenous administration of galactosamine, the endogenous glucosamine takes the place of 1,4-linked α-glucose residues. It is found in both the outer and inner chains of the glycogen molecule.

Original languageEnglish (US)
Pages (from-to)6-11
Number of pages6
JournalFEBS letters
Volume194
Issue number1
DOIs
StatePublished - Jan 1 1986

Keywords

  • Galactosamine
  • Glucosamine
  • Kidney glycogen
  • Liver glycogen
  • N-Methylglucosamine

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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