Glucosamine is a normal component of liver glycogen

Brent R. Kirkman; William J. Whelan

doi:10.1016/0014-5793(86)80041-2

Glucosamine is a normal component of liver glycogen

Brent R. Kirkman, William J. Whelan

Biochemistry & Molecular Biology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

There have been several reports of the incorporation of glucosamine into liver glycogen by an intraperitoneal injection of galactosamine, but it has not previously been considered that glucosamine is a normal component of liver glycogen. We now report that glucosamine occurs endogenously in rabbit- and pig-liver glycogens in the amount of about 1 nmol per 10 mg glycogen. Like the glucosamine incorporated by exogenous administration of galactosamine, the endogenous glucosamine takes the place of 1,4-linked α-glucose residues. It is found in both the outer and inner chains of the glycogen molecule.

Original language	English (US)
Pages (from-to)	6-11
Number of pages	6
Journal	FEBS letters
Volume	194
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(86)80041-2
State	Published - Jan 1 1986

Keywords

Galactosamine
Glucosamine
Kidney glycogen
Liver glycogen
N-Methylglucosamine

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

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title = "Glucosamine is a normal component of liver glycogen",

abstract = "There have been several reports of the incorporation of glucosamine into liver glycogen by an intraperitoneal injection of galactosamine, but it has not previously been considered that glucosamine is a normal component of liver glycogen. We now report that glucosamine occurs endogenously in rabbit- and pig-liver glycogens in the amount of about 1 nmol per 10 mg glycogen. Like the glucosamine incorporated by exogenous administration of galactosamine, the endogenous glucosamine takes the place of 1,4-linked α-glucose residues. It is found in both the outer and inner chains of the glycogen molecule.",

keywords = "Galactosamine, Glucosamine, Kidney glycogen, Liver glycogen, N-Methylglucosamine",

author = "Kirkman, {Brent R.} and Whelan, {William J.}",

note = "Funding Information: This work was supportedb y a grant from the Florida Affiliate of the American Heart Association.",

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T1 - Glucosamine is a normal component of liver glycogen

AU - Kirkman, Brent R.

AU - Whelan, William J.

N1 - Funding Information: This work was supportedb y a grant from the Florida Affiliate of the American Heart Association.

PY - 1986/1/1

Y1 - 1986/1/1

N2 - There have been several reports of the incorporation of glucosamine into liver glycogen by an intraperitoneal injection of galactosamine, but it has not previously been considered that glucosamine is a normal component of liver glycogen. We now report that glucosamine occurs endogenously in rabbit- and pig-liver glycogens in the amount of about 1 nmol per 10 mg glycogen. Like the glucosamine incorporated by exogenous administration of galactosamine, the endogenous glucosamine takes the place of 1,4-linked α-glucose residues. It is found in both the outer and inner chains of the glycogen molecule.

AB - There have been several reports of the incorporation of glucosamine into liver glycogen by an intraperitoneal injection of galactosamine, but it has not previously been considered that glucosamine is a normal component of liver glycogen. We now report that glucosamine occurs endogenously in rabbit- and pig-liver glycogens in the amount of about 1 nmol per 10 mg glycogen. Like the glucosamine incorporated by exogenous administration of galactosamine, the endogenous glucosamine takes the place of 1,4-linked α-glucose residues. It is found in both the outer and inner chains of the glycogen molecule.

KW - Galactosamine

KW - Glucosamine

KW - Kidney glycogen

KW - Liver glycogen

KW - N-Methylglucosamine

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Glucosamine is a normal component of liver glycogen

Abstract

Keywords

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