Abstract
There have been several reports of the incorporation of glucosamine into liver glycogen by an intraperitoneal injection of galactosamine, but it has not previously been considered that glucosamine is a normal component of liver glycogen. We now report that glucosamine occurs endogenously in rabbit- and pig-liver glycogens in the amount of about 1 nmol per 10 mg glycogen. Like the glucosamine incorporated by exogenous administration of galactosamine, the endogenous glucosamine takes the place of 1,4-linked α-glucose residues. It is found in both the outer and inner chains of the glycogen molecule.
| Original language | English |
|---|---|
| Pages (from-to) | 6-11 |
| Number of pages | 6 |
| Journal | FEBS Letters |
| Volume | 194 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1986 |
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Keywords
- Galactosamine
- Glucosamine
- Kidney glycogen
- Liver glycogen
- N-Methylglucosamine
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
Cite this
Glucosamine is a normal component of liver glycogen. / Kirkman, Brent R.; Whelan, William J.
In: FEBS Letters, Vol. 194, No. 1, 01.01.1986, p. 6-11.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Glucosamine is a normal component of liver glycogen
AU - Kirkman, Brent R.
AU - Whelan, William J.
PY - 1986/1/1
Y1 - 1986/1/1
N2 - There have been several reports of the incorporation of glucosamine into liver glycogen by an intraperitoneal injection of galactosamine, but it has not previously been considered that glucosamine is a normal component of liver glycogen. We now report that glucosamine occurs endogenously in rabbit- and pig-liver glycogens in the amount of about 1 nmol per 10 mg glycogen. Like the glucosamine incorporated by exogenous administration of galactosamine, the endogenous glucosamine takes the place of 1,4-linked α-glucose residues. It is found in both the outer and inner chains of the glycogen molecule.
AB - There have been several reports of the incorporation of glucosamine into liver glycogen by an intraperitoneal injection of galactosamine, but it has not previously been considered that glucosamine is a normal component of liver glycogen. We now report that glucosamine occurs endogenously in rabbit- and pig-liver glycogens in the amount of about 1 nmol per 10 mg glycogen. Like the glucosamine incorporated by exogenous administration of galactosamine, the endogenous glucosamine takes the place of 1,4-linked α-glucose residues. It is found in both the outer and inner chains of the glycogen molecule.
KW - Galactosamine
KW - Glucosamine
KW - Kidney glycogen
KW - Liver glycogen
KW - N-Methylglucosamine
UR - http://www.scopus.com/inward/record.url?scp=0022639509&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022639509&partnerID=8YFLogxK
U2 - 10.1016/0014-5793(86)80041-2
DO - 10.1016/0014-5793(86)80041-2
M3 - Article
C2 - 3079709
AN - SCOPUS:0022639509
VL - 194
SP - 6
EP - 11
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 1
ER -