Glucocorticoid receptors in subpopulations of childhood acute lymphocytic leukemia

G. S. Konior Yarbro, Marc E Lippman, G. E. Johnson, B. G. Leventhal

Research output: Contribution to journalArticle

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Abstract

In view of the known differences in sensitivity to glucocorticoids among functional subcategories of lymphocytes in the mouse and the awareness that different subcategories of acute lymphocytic leukemia may represent proliferation of different clones of lymphoblasts, we examined lymphoblast populations with known surface markers for differences in specific cytoplasmic glucocorticoid receptor activity. Lymphoblasts were divided into those that formed sheep erythrocyte rosettes (T lymphoblasts) and those that lacked all surface markers (null lymphoblasts). The latter were further subdivided by their ability to stimulate allogeneic donors in mixed lymphocyte culture (MLC). Lack of stimulation in MLC is a characteristic of mature T cells. Eighteen patients had null lymphoblasts that did stimulate in MLC, and glucocorticoid binding sites in these ranged from 4,096 to 21,869 sites/cell (median, 7,571). Eighteen patients with T lymphoblasts had binding sites ranging from 0 to 5,887 sites/cell (median, 2,173). This difference in specific glucocorticoid receptor levels is highly significant (p < 0.001). Nine patients whose lymphoblasts lacked identifiable surface markers but failed to stimulate in MLC had intermediate values for receptor sites. Thus it appears that null lymphoblasts are more likely to have higher numbers of specific glucocorticoid receptor than T lymphoblasts. The differential capacity of lymphoblasts to bind steroid may prove useful in designing therapeutic regimens for the different subcategories of acute lymphocytic leukemia.

Original languageEnglish
JournalCancer Research
Volume37
Issue number8
StatePublished - Dec 1 1977
Externally publishedYes

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Glucocorticoid Receptors
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Lymphocytes
Glucocorticoids
Binding Sites
Cytoplasmic and Nuclear Receptors
Sheep
Clone Cells
Erythrocytes
Steroids
Tissue Donors
T-Lymphocytes
Population

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Konior Yarbro, G. S., Lippman, M. E., Johnson, G. E., & Leventhal, B. G. (1977). Glucocorticoid receptors in subpopulations of childhood acute lymphocytic leukemia. Cancer Research, 37(8).

Glucocorticoid receptors in subpopulations of childhood acute lymphocytic leukemia. / Konior Yarbro, G. S.; Lippman, Marc E; Johnson, G. E.; Leventhal, B. G.

In: Cancer Research, Vol. 37, No. 8, 01.12.1977.

Research output: Contribution to journalArticle

Konior Yarbro, GS, Lippman, ME, Johnson, GE & Leventhal, BG 1977, 'Glucocorticoid receptors in subpopulations of childhood acute lymphocytic leukemia', Cancer Research, vol. 37, no. 8.
Konior Yarbro GS, Lippman ME, Johnson GE, Leventhal BG. Glucocorticoid receptors in subpopulations of childhood acute lymphocytic leukemia. Cancer Research. 1977 Dec 1;37(8).
Konior Yarbro, G. S. ; Lippman, Marc E ; Johnson, G. E. ; Leventhal, B. G. / Glucocorticoid receptors in subpopulations of childhood acute lymphocytic leukemia. In: Cancer Research. 1977 ; Vol. 37, No. 8.
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