Glucocorticoid receptors in purified subpopulations of human peripheral blood lymphocytes

Marc E Lippman, R. Barr

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Abstract

On the premise that the differential effects of glucocorticoids on various aspects of the immune response may be mediated by differences in the glucocorticoid receptors in the effector cells, subpopulations of human peripheral blood lymphocytes were examined for these receptors as well as for glucocorticoid responsiveness. Purified T and non T lymphocytes, when studied by a sensitive whole cell assay technique, contained equivalent amounts of specific glucocorticoid receptor, which, by binding affinity and specificity measurements, were indistinguishable from each other. Furthermore, under in vitro incubation conditions, macromolecular synthesis in both of these cell populations was inhibited by glucocorticoid at concentrations which saturated the receptor sites. It is concluded that the putative differential effects of glucocorticoids on T and non T lymphocyte associated functions are probably not mediated by differences in the glucocorticoid receptors in these cell populations.

Original languageEnglish
Pages (from-to)1977-1981
Number of pages5
JournalJournal of Immunology
Volume118
Issue number6
StatePublished - Dec 1 1977
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology

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