Glucocorticoid receptors. Characteristics, specificity, and ontogenesis in the embryonic chick neural retina

M. E. Lippman, B. O. Wiggert, G. J. Chader, E. B. Thompson

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

Specific glucocorticoid receptors from chick embryonic neural retina are demonstrable as early as 6 days in ovo. The receptor also binds progesterone with high affinity. Despite marked increases in glucocorticoid provoked glutamine synthetase activity after Day 6, no increase in cytoplasmic receptor concentration occurs. Thus control of enzyme induction does not seem to depend simply on the presence of cytoplasmic steroid receptors but seems to be mediated by steps subsequent to the initial binding of hormone to receptor.

Original languageEnglish (US)
Pages (from-to)5916-5917
Number of pages2
JournalJournal of Biological Chemistry
Volume249
Issue number18
StatePublished - Dec 1 1974

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Lippman, M. E., Wiggert, B. O., Chader, G. J., & Thompson, E. B. (1974). Glucocorticoid receptors. Characteristics, specificity, and ontogenesis in the embryonic chick neural retina. Journal of Biological Chemistry, 249(18), 5916-5917.