Glucocorticoid receptor polymorphisms and intraocular pressure response to intravitreal triamcinolone acetonide

Sabrina M. Gerzenstein, Mathew T. Pletcher, Alessandra C L Cervino, Nicholas Tsinoremas, Brandon Young, Carmen A. Puliafito, M. Elizabeth Fini, Stephen Schwartz

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: Elevation of intraocular pressure (IOP) following injection of intravitreal triamcinolone acetonide (IVTA) is an important clinical problem. The etiology of the steroid response is poorly understood, although a genetic determinant has long been suspected. We performed a pharmacogenomic association study with glucocorticoid receptor polymorphisms. Materials and Methods: Fifty-two patients (56 eyes) who underwent treatment with IVTA for various retinal diseases were genotyped for six well-studied glucocorticoid receptor polymorphisms (ER22/23EK, N363S, BclI, N766N, and single nucleotide polymorphisms (SNPs) within introns 3 and 4). Results: Three polymorphisms (ER22/23EK, N363S, and the intron 3 SNP) were essentially nonpolymorphic within this population sample and excluded from further analysis. The remaining three polymorphisms (BclI, N766N, and within intron 4) passed the Hardy-Weinberg Equilibrium test, indicating good genotyping quality and normal population distribution of allelic frequency. No statistically significant correlations were found between these three polymorphisms and magnitude of IOP elevation following IVTA, using single point association and haplotype analyses. Conclusions: In this small, pilot study, we found no statistically significant relationship between glucocorticoid receptor polymorphisms and IOP elevation following IVTA. The precise etiology of the steroid response remains obscure. To our knowledge, this is the first published pharmacogenomic study of this common clinical entity.

Original languageEnglish
Pages (from-to)166-170
Number of pages5
JournalOphthalmic Genetics
Volume29
Issue number4
DOIs
StatePublished - Dec 1 2008

Fingerprint

Triamcinolone Acetonide
Glucocorticoid Receptors
Intraocular Pressure
Introns
Single Nucleotide Polymorphism
Steroids
Retinal Diseases
Intravitreal Injections
Normal Distribution
Haplotypes
Demography
Population
Pharmacogenomic Testing
Therapeutics

Keywords

  • Glucocorticoid receptor
  • Polymorphisms
  • Steroid response
  • Triamcinolone acetonide

ASJC Scopus subject areas

  • Ophthalmology
  • Pediatrics, Perinatology, and Child Health
  • Genetics(clinical)

Cite this

Glucocorticoid receptor polymorphisms and intraocular pressure response to intravitreal triamcinolone acetonide. / Gerzenstein, Sabrina M.; Pletcher, Mathew T.; Cervino, Alessandra C L; Tsinoremas, Nicholas; Young, Brandon; Puliafito, Carmen A.; Fini, M. Elizabeth; Schwartz, Stephen.

In: Ophthalmic Genetics, Vol. 29, No. 4, 01.12.2008, p. 166-170.

Research output: Contribution to journalArticle

Gerzenstein, Sabrina M. ; Pletcher, Mathew T. ; Cervino, Alessandra C L ; Tsinoremas, Nicholas ; Young, Brandon ; Puliafito, Carmen A. ; Fini, M. Elizabeth ; Schwartz, Stephen. / Glucocorticoid receptor polymorphisms and intraocular pressure response to intravitreal triamcinolone acetonide. In: Ophthalmic Genetics. 2008 ; Vol. 29, No. 4. pp. 166-170.
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