Glucagon regulates its own synthesis by autocrine signaling

Barbara Leibiger, Tilo Moede, Thusitha P. Muhandiramlage, Daniel Kaiser, Pilar Vaca Sanchez, Ingo B. Leibiger, Per Olof Berggren

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Peptide hormones are powerful regulators of various biological processes. To guarantee continuous availability and function, peptide hormone secretion must be tightly coupled to its biosynthesis. A simple but efficient way to provide such regulation is through an autocrine feedback mechanism in which the secreted hormone is "sensed" by its respective receptor and initiates synthesis at the level of transcription and/or translation. Such a secretion-biosynthesis coupling has been demonstrated for insulin; however, because of insulin's unique role as the sole blood glucose-decreasing peptide hormone, this coupling is considered an exception rather than a more generally used mechanism. Here we provide evidence of a secretion-biosynthesis coupling for glucagon, one of several peptide hormones that increase blood glucose levels. We show that glucagon, secreted by the pancreatic α cell, up-regulates the expression of its own gene by signaling through the glucagon receptor, PKC, and PKA, supporting the more general applicability of an autocrine feedback mechanism in regulation of peptide hormone synthesis.

Original languageEnglish (US)
Pages (from-to)20925-20930
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number51
StatePublished - Dec 18 2012
Externally publishedYes


  • Gene expression
  • Signal transduction

ASJC Scopus subject areas

  • General


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