Glucagon regulates its own synthesis by autocrine signaling

Barbara Leibiger, Tilo Moede, Thusitha P. Muhandiramlage, Daniel Kaiser, Pilar Vaca Sanchez, Ingo B. Leibiger, Per Olof Berggren

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Peptide hormones are powerful regulators of various biological processes. To guarantee continuous availability and function, peptide hormone secretion must be tightly coupled to its biosynthesis. A simple but efficient way to provide such regulation is through an autocrine feedback mechanism in which the secreted hormone is "sensed" by its respective receptor and initiates synthesis at the level of transcription and/or translation. Such a secretion-biosynthesis coupling has been demonstrated for insulin; however, because of insulin's unique role as the sole blood glucose-decreasing peptide hormone, this coupling is considered an exception rather than a more generally used mechanism. Here we provide evidence of a secretion-biosynthesis coupling for glucagon, one of several peptide hormones that increase blood glucose levels. We show that glucagon, secreted by the pancreatic α cell, up-regulates the expression of its own gene by signaling through the glucagon receptor, PKC, and PKA, supporting the more general applicability of an autocrine feedback mechanism in regulation of peptide hormone synthesis.

Original languageEnglish
Pages (from-to)20925-20930
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume109
Issue number51
DOIs
StatePublished - Dec 18 2012
Externally publishedYes

Fingerprint

Autocrine Communication
Peptide Hormones
Glucagon
Blood Glucose
Glucagon Receptors
Biological Phenomena
Up-Regulation
Hormones
Insulin
Genes

Keywords

  • Gene expression
  • Signal transduction

ASJC Scopus subject areas

  • General

Cite this

Leibiger, B., Moede, T., Muhandiramlage, T. P., Kaiser, D., Sanchez, P. V., Leibiger, I. B., & Berggren, P. O. (2012). Glucagon regulates its own synthesis by autocrine signaling. Proceedings of the National Academy of Sciences of the United States of America, 109(51), 20925-20930. https://doi.org/10.1073/pnas.1212870110

Glucagon regulates its own synthesis by autocrine signaling. / Leibiger, Barbara; Moede, Tilo; Muhandiramlage, Thusitha P.; Kaiser, Daniel; Sanchez, Pilar Vaca; Leibiger, Ingo B.; Berggren, Per Olof.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, No. 51, 18.12.2012, p. 20925-20930.

Research output: Contribution to journalArticle

Leibiger, B, Moede, T, Muhandiramlage, TP, Kaiser, D, Sanchez, PV, Leibiger, IB & Berggren, PO 2012, 'Glucagon regulates its own synthesis by autocrine signaling', Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 51, pp. 20925-20930. https://doi.org/10.1073/pnas.1212870110
Leibiger B, Moede T, Muhandiramlage TP, Kaiser D, Sanchez PV, Leibiger IB et al. Glucagon regulates its own synthesis by autocrine signaling. Proceedings of the National Academy of Sciences of the United States of America. 2012 Dec 18;109(51):20925-20930. https://doi.org/10.1073/pnas.1212870110
Leibiger, Barbara ; Moede, Tilo ; Muhandiramlage, Thusitha P. ; Kaiser, Daniel ; Sanchez, Pilar Vaca ; Leibiger, Ingo B. ; Berggren, Per Olof. / Glucagon regulates its own synthesis by autocrine signaling. In: Proceedings of the National Academy of Sciences of the United States of America. 2012 ; Vol. 109, No. 51. pp. 20925-20930.
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