GLUCAGON CONTROL OF FASTING GLUCOSE IN MAN

F. P. Alford, S. R. Bloom, J. D N Nabarro, R. Hall, G. M. Besser, D. H. Coy, A. J. Kastin, Andrew V Schally

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Infusion of growth-hormone release inhibiting hormone (G.H.-R.I.H.) in four fasting subjects reduced plasma glucagon and insulin concentrations to undetectable levels and this was associated with a highly significant decline in plasma-glucose (28±S.E.M. 3 mg. per 100 ml. in 1 hour, p< 001). When plasma-glucagon was maintained by an exogenous infusion, at a level which did not itself significantly alter glucose or insulin concentrations, G.H.-R.I.H. administration resulted in a rise in the mean plasma-glucose (20±10 mg. per 100 ml.). It is concluded that, in man, glucagon plays an important part in the maintenance of fasting plasma-glucose.

Original languageEnglish
Pages (from-to)974-977
Number of pages4
JournalThe Lancet
Volume304
Issue number7887
DOIs
StatePublished - Oct 26 1974
Externally publishedYes

Fingerprint

Glucagon
Fasting
Glucose
Growth Hormone
Hormones
Insulin
Maintenance

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Alford, F. P., Bloom, S. R., Nabarro, J. D. N., Hall, R., Besser, G. M., Coy, D. H., ... Schally, A. V. (1974). GLUCAGON CONTROL OF FASTING GLUCOSE IN MAN. The Lancet, 304(7887), 974-977. https://doi.org/10.1016/S0140-6736(74)92071-6

GLUCAGON CONTROL OF FASTING GLUCOSE IN MAN. / Alford, F. P.; Bloom, S. R.; Nabarro, J. D N; Hall, R.; Besser, G. M.; Coy, D. H.; Kastin, A. J.; Schally, Andrew V.

In: The Lancet, Vol. 304, No. 7887, 26.10.1974, p. 974-977.

Research output: Contribution to journalArticle

Alford, FP, Bloom, SR, Nabarro, JDN, Hall, R, Besser, GM, Coy, DH, Kastin, AJ & Schally, AV 1974, 'GLUCAGON CONTROL OF FASTING GLUCOSE IN MAN', The Lancet, vol. 304, no. 7887, pp. 974-977. https://doi.org/10.1016/S0140-6736(74)92071-6
Alford FP, Bloom SR, Nabarro JDN, Hall R, Besser GM, Coy DH et al. GLUCAGON CONTROL OF FASTING GLUCOSE IN MAN. The Lancet. 1974 Oct 26;304(7887):974-977. https://doi.org/10.1016/S0140-6736(74)92071-6
Alford, F. P. ; Bloom, S. R. ; Nabarro, J. D N ; Hall, R. ; Besser, G. M. ; Coy, D. H. ; Kastin, A. J. ; Schally, Andrew V. / GLUCAGON CONTROL OF FASTING GLUCOSE IN MAN. In: The Lancet. 1974 ; Vol. 304, No. 7887. pp. 974-977.
@article{4d13103751ce424286cd287c291ea39e,
title = "GLUCAGON CONTROL OF FASTING GLUCOSE IN MAN",
abstract = "Infusion of growth-hormone release inhibiting hormone (G.H.-R.I.H.) in four fasting subjects reduced plasma glucagon and insulin concentrations to undetectable levels and this was associated with a highly significant decline in plasma-glucose (28±S.E.M. 3 mg. per 100 ml. in 1 hour, p< 001). When plasma-glucagon was maintained by an exogenous infusion, at a level which did not itself significantly alter glucose or insulin concentrations, G.H.-R.I.H. administration resulted in a rise in the mean plasma-glucose (20±10 mg. per 100 ml.). It is concluded that, in man, glucagon plays an important part in the maintenance of fasting plasma-glucose.",
author = "Alford, {F. P.} and Bloom, {S. R.} and Nabarro, {J. D N} and R. Hall and Besser, {G. M.} and Coy, {D. H.} and Kastin, {A. J.} and Schally, {Andrew V}",
year = "1974",
month = "10",
day = "26",
doi = "10.1016/S0140-6736(74)92071-6",
language = "English",
volume = "304",
pages = "974--977",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Elsevier Limited",
number = "7887",

}

TY - JOUR

T1 - GLUCAGON CONTROL OF FASTING GLUCOSE IN MAN

AU - Alford, F. P.

AU - Bloom, S. R.

AU - Nabarro, J. D N

AU - Hall, R.

AU - Besser, G. M.

AU - Coy, D. H.

AU - Kastin, A. J.

AU - Schally, Andrew V

PY - 1974/10/26

Y1 - 1974/10/26

N2 - Infusion of growth-hormone release inhibiting hormone (G.H.-R.I.H.) in four fasting subjects reduced plasma glucagon and insulin concentrations to undetectable levels and this was associated with a highly significant decline in plasma-glucose (28±S.E.M. 3 mg. per 100 ml. in 1 hour, p< 001). When plasma-glucagon was maintained by an exogenous infusion, at a level which did not itself significantly alter glucose or insulin concentrations, G.H.-R.I.H. administration resulted in a rise in the mean plasma-glucose (20±10 mg. per 100 ml.). It is concluded that, in man, glucagon plays an important part in the maintenance of fasting plasma-glucose.

AB - Infusion of growth-hormone release inhibiting hormone (G.H.-R.I.H.) in four fasting subjects reduced plasma glucagon and insulin concentrations to undetectable levels and this was associated with a highly significant decline in plasma-glucose (28±S.E.M. 3 mg. per 100 ml. in 1 hour, p< 001). When plasma-glucagon was maintained by an exogenous infusion, at a level which did not itself significantly alter glucose or insulin concentrations, G.H.-R.I.H. administration resulted in a rise in the mean plasma-glucose (20±10 mg. per 100 ml.). It is concluded that, in man, glucagon plays an important part in the maintenance of fasting plasma-glucose.

UR - http://www.scopus.com/inward/record.url?scp=0016215903&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016215903&partnerID=8YFLogxK

U2 - 10.1016/S0140-6736(74)92071-6

DO - 10.1016/S0140-6736(74)92071-6

M3 - Article

C2 - 4138107

AN - SCOPUS:0016215903

VL - 304

SP - 974

EP - 977

JO - The Lancet

JF - The Lancet

SN - 0140-6736

IS - 7887

ER -