GLUCAGON CONTROL OF FASTING GLUCOSE IN MAN

F. P. Alford, S. R. Bloom, J. D.N. Nabarro, R. Hall, G. M. Besser, D. H. Coy, A. J. Kastin, A. V. Schally

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86 Scopus citations

Abstract

Infusion of growth-hormone release inhibiting hormone (G.H.-R.I.H.) in four fasting subjects reduced plasma glucagon and insulin concentrations to undetectable levels and this was associated with a highly significant decline in plasma-glucose (28±S.E.M. 3 mg. per 100 ml. in 1 hour, p< 001). When plasma-glucagon was maintained by an exogenous infusion, at a level which did not itself significantly alter glucose or insulin concentrations, G.H.-R.I.H. administration resulted in a rise in the mean plasma-glucose (20±10 mg. per 100 ml.). It is concluded that, in man, glucagon plays an important part in the maintenance of fasting plasma-glucose.

Original languageEnglish (US)
Pages (from-to)974-977
Number of pages4
JournalThe Lancet
Volume304
Issue number7887
DOIs
StatePublished - Oct 26 1974
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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