GLP-1 mediated improvement of the glucose tolerance in the T2DM GK rat model after massive jejunal resection

J. Arturo Prada-Oliveira, Alonso Camacho-Ramirez, Jesús Salas-Alvarez, Francisco Javier Campos-Martinez, Alfonso M. Lechuga-Sancho, David Almorza-Gomar, Manuel Blandino-Rosano, Gonzalo M. Perez-Arana

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Objective: The aim of this study was to clarify the role of the middle gut in the entero-pancreatic axis modification that leads to glucose improvement in the Goto-Kakizaki (GK) rat as a non-obese T2DM model. Background: Bariatric surgery is considered an assured solution for type 2 Diabetes (T2DM). Enterohormones such as ghrelin, gastric inhibitory polypeptide and mainly glucagon-like peptide-1 (GLP-1) were recognized as key players in the physiophathological mechanisms associated with entero-pancreatic axis regulation and glucose tolerance improvement. However, the influence of anatomical arrangements post-bariatric surgery on this axis is still debatable. Method: To this purpose, 50% of small intestine resections were performed on GK rats (n = 6), preserving the proximal half of the jejunum and the ileum (IR50). Phenotypic and functional changes, such as performance in oral glucose tolerance tests, ileal release of GLP-1, beta-cell sensitivity to GLP-1, beta-cell mass, and turnover were characterized in IR50 and the surgical control group (Sham). Results: The glucose tolerance was improved and ileal release of GLP-1 was enhanced four weeks after IR50 versus the control group rats. Beta-cell mass, beta-cell proliferation, and beta-cell sensitivity to GLP-1 were also increased in the pancreas of IR50 versus the control group rats. Conclusion: the jejunal exclusion increases beta-cell-mass and improves glucose tolerance by increasing in GLP-1 expression and number of receptors via the entero-pancreatic axis.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalAnnals of Anatomy
Volume223
DOIs
StatePublished - May 2019

Keywords

  • Enterohormones
  • GLP-1
  • Insulin-Secreting Cells
  • Malabsorption Syndromes
  • type 2 Diabetes mellitus

ASJC Scopus subject areas

  • Anatomy
  • Developmental Biology

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