Abstract
The glomerular mesangium is composed of mesangial cells and an intercellular material, the mesangial matrix. Partly because of its unique anatomic location, the mesangium appears to be susceptible to immune- and non-immune-mediated injury. Mesangial cells have characteristics similar to smooth muscle cells, and their surface is covered with receptors that bind a variety of vasoactive substances. The glomerular mesangium seems to play an important role in the physiologic regulation of the glomerular microcirculation. There is evidence that a plasmic flow carrying macromolecules circulates through the mesangium. Changes in glomerular hemodynamic determinants and in the release and/or production of vasoactive substances, particularly angiotensin II, can greatly influence the mesangial movement of macromolecules. Quantitative and/or qualitative alterations in the mesangial movement of macromolecules may lead to mesangial injury.
| Original language | English |
|---|---|
| Pages (from-to) | 24-30 |
| Number of pages | 7 |
| Journal | The American Journal of Medicine |
| Volume | 79 |
| Issue number | 3 SUPPL. 3 |
| DOIs | |
| State | Published - Sep 27 1985 |
| Externally published | Yes |
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Glomerular mesangium : Its function and relationship to angiotensin II. / Raij, Leopoldo; Keane, William F.
In: The American Journal of Medicine, Vol. 79, No. 3 SUPPL. 3, 27.09.1985, p. 24-30.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Glomerular mesangium
T2 - Its function and relationship to angiotensin II
AU - Raij, Leopoldo
AU - Keane, William F.
PY - 1985/9/27
Y1 - 1985/9/27
N2 - The glomerular mesangium is composed of mesangial cells and an intercellular material, the mesangial matrix. Partly because of its unique anatomic location, the mesangium appears to be susceptible to immune- and non-immune-mediated injury. Mesangial cells have characteristics similar to smooth muscle cells, and their surface is covered with receptors that bind a variety of vasoactive substances. The glomerular mesangium seems to play an important role in the physiologic regulation of the glomerular microcirculation. There is evidence that a plasmic flow carrying macromolecules circulates through the mesangium. Changes in glomerular hemodynamic determinants and in the release and/or production of vasoactive substances, particularly angiotensin II, can greatly influence the mesangial movement of macromolecules. Quantitative and/or qualitative alterations in the mesangial movement of macromolecules may lead to mesangial injury.
AB - The glomerular mesangium is composed of mesangial cells and an intercellular material, the mesangial matrix. Partly because of its unique anatomic location, the mesangium appears to be susceptible to immune- and non-immune-mediated injury. Mesangial cells have characteristics similar to smooth muscle cells, and their surface is covered with receptors that bind a variety of vasoactive substances. The glomerular mesangium seems to play an important role in the physiologic regulation of the glomerular microcirculation. There is evidence that a plasmic flow carrying macromolecules circulates through the mesangium. Changes in glomerular hemodynamic determinants and in the release and/or production of vasoactive substances, particularly angiotensin II, can greatly influence the mesangial movement of macromolecules. Quantitative and/or qualitative alterations in the mesangial movement of macromolecules may lead to mesangial injury.
UR - http://www.scopus.com/inward/record.url?scp=0022367763&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022367763&partnerID=8YFLogxK
U2 - 10.1016/0002-9343(85)90076-2
DO - 10.1016/0002-9343(85)90076-2
M3 - Article
C2 - 4050826
AN - SCOPUS:0022367763
VL - 79
SP - 24
EP - 30
JO - American Journal of Medicine
JF - American Journal of Medicine
SN - 0002-9343
IS - 3 SUPPL. 3
ER -