TY - JOUR
T1 - Glomerular mesangium
T2 - Its function and relationship to angiotensin II
AU - Raij, Leopoldo
AU - Keane, William F.
N1 - Funding Information:
From the Department of Medicine, University Minnesota Medical School, Veterans Administration Medical Center, and Hennepin County Medical Center, Minneapolis, Minnesota. This study was supported by a grant (HL-29720) from the National Institutes of Health and by funds from the Veterans Administration. Requests for reprints should be addressed to Dr. Leopold0 Raij, Veterans Administration Medical Center, Renal Section IIIJ, 54th Street and 48th Avenue South, Minneapolis, Minnesota 55417.
PY - 1985/9/27
Y1 - 1985/9/27
N2 - The glomerular mesangium is composed of mesangial cells and an intercellular material, the mesangial matrix. Partly because of its unique anatomic location, the mesangium appears to be susceptible to immune- and non-immune-mediated injury. Mesangial cells have characteristics similar to smooth muscle cells, and their surface is covered with receptors that bind a variety of vasoactive substances. The glomerular mesangium seems to play an important role in the physiologic regulation of the glomerular microcirculation. There is evidence that a plasmic flow carrying macromolecules circulates through the mesangium. Changes in glomerular hemodynamic determinants and in the release and/or production of vasoactive substances, particularly angiotensin II, can greatly influence the mesangial movement of macromolecules. Quantitative and/or qualitative alterations in the mesangial movement of macromolecules may lead to mesangial injury.
AB - The glomerular mesangium is composed of mesangial cells and an intercellular material, the mesangial matrix. Partly because of its unique anatomic location, the mesangium appears to be susceptible to immune- and non-immune-mediated injury. Mesangial cells have characteristics similar to smooth muscle cells, and their surface is covered with receptors that bind a variety of vasoactive substances. The glomerular mesangium seems to play an important role in the physiologic regulation of the glomerular microcirculation. There is evidence that a plasmic flow carrying macromolecules circulates through the mesangium. Changes in glomerular hemodynamic determinants and in the release and/or production of vasoactive substances, particularly angiotensin II, can greatly influence the mesangial movement of macromolecules. Quantitative and/or qualitative alterations in the mesangial movement of macromolecules may lead to mesangial injury.
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U2 - 10.1016/0002-9343(85)90076-2
DO - 10.1016/0002-9343(85)90076-2
M3 - Article
C2 - 4050826
AN - SCOPUS:0022367763
VL - 79
SP - 24
EP - 30
JO - American Journal of Medicine
JF - American Journal of Medicine
SN - 0002-9343
IS - 3 SUPPL. 3
ER -