Glomerular mesangium: Its function and relationship to angiotensin II

Leopoldo Raij, William F. Keane

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

The glomerular mesangium is composed of mesangial cells and an intercellular material, the mesangial matrix. Partly because of its unique anatomic location, the mesangium appears to be susceptible to immune- and non-immune-mediated injury. Mesangial cells have characteristics similar to smooth muscle cells, and their surface is covered with receptors that bind a variety of vasoactive substances. The glomerular mesangium seems to play an important role in the physiologic regulation of the glomerular microcirculation. There is evidence that a plasmic flow carrying macromolecules circulates through the mesangium. Changes in glomerular hemodynamic determinants and in the release and/or production of vasoactive substances, particularly angiotensin II, can greatly influence the mesangial movement of macromolecules. Quantitative and/or qualitative alterations in the mesangial movement of macromolecules may lead to mesangial injury.

Original languageEnglish
Pages (from-to)24-30
Number of pages7
JournalThe American Journal of Medicine
Volume79
Issue number3 SUPPL. 3
DOIs
StatePublished - Sep 27 1985
Externally publishedYes

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Glomerular Mesangium
Mesangial Cells
Angiotensin II
Wounds and Injuries
Microcirculation
Smooth Muscle Myocytes
Hemodynamics

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Glomerular mesangium : Its function and relationship to angiotensin II. / Raij, Leopoldo; Keane, William F.

In: The American Journal of Medicine, Vol. 79, No. 3 SUPPL. 3, 27.09.1985, p. 24-30.

Research output: Contribution to journalArticle

Raij, Leopoldo ; Keane, William F. / Glomerular mesangium : Its function and relationship to angiotensin II. In: The American Journal of Medicine. 1985 ; Vol. 79, No. 3 SUPPL. 3. pp. 24-30.
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