Glomerular lesions in the acquired immunodeficiency syndrome

V. Pardo, M. Aldana, R. M. Colton, M. A. Fischl, D. Jaffe, L. Moskowitz, G. T. Hensley, J. J. Bourgoignie

Research output: Contribution to journalArticlepeer-review

244 Scopus citations


Between January 1982 and December 1983, 75 patients with the acquired immunodeficiency syndrome were identified in our hospitals: 35% used intravenous drugs, 50% had proteinuria in excess of 0.5 g/dL, and 10% were nephrotic. Glomerular changes seen at autopsy in 36 patients included frequent mesangial lesions and deposits associated with mild asymptomatic proteinuria. Focal and segmental glomerular sclerosis was found in 5 patients and 4 of these had the nephrotic syndrome. Whereas reversible episodes of acute renal failure were not uncommon, terminal episodes of acute renal insufficiency occurred in 14 patients. The short survival of these patients may prevent the development of chronic renal failure.

Original languageEnglish (US)
Pages (from-to)429-434
Number of pages6
JournalAnnals of internal medicine
Issue number4
StatePublished - 1984
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine


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