Glomerular function and morphology after renal mass reduction in dogs

Jacques J. Bourgoignie, George Gavellas, Esteban Martinez, Victoriano Pardo

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

To determine whether the proteinuria, glomerular sclerosis, and decline in glomerular filtration rate (GFR) described in rodents after renal mass reduction develop in another species, 24-hour proteinuria, glomerular structure, and fasting and postfeeding GFR were examined in dogs subjected to seven-eighths reduction in renal mass. All dogs were fed a diet containing 26% protein. Six dogs with a GFR <10 ml/min (8% to 17% of control two-kidney GFR) were killed within 6 months after renal mass reduction. Twenty-four-hour urinary protein excretion was modestly although definitely increased (236 ± 26 mg/24 hr, P < 0.01). All remnant kidneys demonstrated structural changes of mesangial hyperplasia or focal glomerular sclerosis. Ten dogs with a remnant kidney and early GFRs 16% to 39% of control values were followed for 18 to 39 months. In seven dogs, GFR showed little tendency to decrease with time. In one of them, proteinuria was 106 mg/24 hr with normal-appearing glomeruli at 14 months. In three dogs, proteinuria was progressive, averaging about 1 gm/24 hr at 18 months and 2 gm/24 hr at 24 to 34 months; glomerular pathologic findings progressed from focal mesangial hyperplasia or focal glomerular sclerosis at 8 to 16 months to focal and segmental sclerosis or diffuse glomerular obsolescence at 25 to 34 months; and fasting GFR progressively declined starting at 21 to 24 months after renal mass reduction. Whereas GFR increased after feeding 1 to 2 gm protein per kilogram much less (P < 0.01) in dogs with a remnant kidney (from 15.9 ± 1.4 to 19.8 ± 1.7 ml/min) than in normal dogs (from 42.7 ± 1.8 to 53.9 ± 2.1 ml/min), the relative increase in GFR was equivalent, 24.3% ± 3.4% vs. 27.1% ± 3.9%, in the two groups. Thus, reduction of renal mass in dogs, as in rodents, results in a proteinuric glomerulopathy, the severity of which appears proportional to the amount of renal mass ablated and which precedes the decline in GFR. The presence of a glomerular filtration reserve in fasting dogs with a remnant kidney may help support GFR and delay its progressive decline.

Original languageEnglish
Pages (from-to)378-379
Number of pages2
JournalThe Journal of laboratory and clinical medicine
Volume109
Issue number4
StatePublished - Jan 1 1987

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Glomerular Filtration Rate
Dogs
Kidney
Sclerosis
Proteinuria
Fasting
Hyperplasia
Rodentia
Obsolescence
Proteins
Nutrition
Diet

ASJC Scopus subject areas

  • Medicine(all)
  • Pathology and Forensic Medicine

Cite this

Bourgoignie, J. J., Gavellas, G., Martinez, E., & Pardo, V. (1987). Glomerular function and morphology after renal mass reduction in dogs. The Journal of laboratory and clinical medicine, 109(4), 378-379.

Glomerular function and morphology after renal mass reduction in dogs. / Bourgoignie, Jacques J.; Gavellas, George; Martinez, Esteban; Pardo, Victoriano.

In: The Journal of laboratory and clinical medicine, Vol. 109, No. 4, 01.01.1987, p. 378-379.

Research output: Contribution to journalArticle

Bourgoignie, JJ, Gavellas, G, Martinez, E & Pardo, V 1987, 'Glomerular function and morphology after renal mass reduction in dogs', The Journal of laboratory and clinical medicine, vol. 109, no. 4, pp. 378-379.
Bourgoignie JJ, Gavellas G, Martinez E, Pardo V. Glomerular function and morphology after renal mass reduction in dogs. The Journal of laboratory and clinical medicine. 1987 Jan 1;109(4):378-379.
Bourgoignie, Jacques J. ; Gavellas, George ; Martinez, Esteban ; Pardo, Victoriano. / Glomerular function and morphology after renal mass reduction in dogs. In: The Journal of laboratory and clinical medicine. 1987 ; Vol. 109, No. 4. pp. 378-379.
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