Glomerular aging in females is a multi-stage reversible process mediated by phenotypic changes in progenitors

Zheng Feng, Anna Rita Plati, Qing Li Cheng, Mariana Berho, Anita Banerjee, Mylene Potier, Wenche Jy, Andrew Koff, Liliane J. Striker, Gary E. Striker

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The glomeruli of postmenopausal C57BL6 mice, and age-matched, males, show progressive hypertrophy and glomerulosclerosis. We asked whether this was a multistage process, was due to alterations in glomerular progenitors, and was reversible in female mice. Using cross bone marrow transplants (BMT) between young and old females, we found that BMT delivered a phenotype that was donor age-specific. The fact that lesions in young recipients were more severe if the donors were in late rather than early menopause suggested that new progenitor phenotypes had appeared. Postmenopausal recipients of BMT from young donors had reduced glomerular hypertrophy and sclerosis, implying that the aging lesions in females were reversible and that progenitors, rather than the local environment, determined the glomerular profile. The altered phenotype included increased extracellular matrix synthesis and decreased matrix metalloproteinase-2 levels as well as cell hypertrophy. The mechanism of the cellular hypertrophy was due to uncoupling of hypertrophy from proliferation, resulting from elevated p27 levels. Thus, glomerular hypertrophy and sclerosis in aging females is a multistage process, is reversible, and may be determined by the phenotype of bone marrow-derived progenitor cells.

Original languageEnglish
Pages (from-to)355-363
Number of pages9
JournalAmerican Journal of Pathology
Volume167
Issue number2
StatePublished - Aug 1 2005

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Hypertrophy
Bone Marrow
Phenotype
Sclerosis
Transplants
Matrix Metalloproteinase 2
Menopause
Extracellular Matrix
Stem Cells

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Feng, Z., Plati, A. R., Cheng, Q. L., Berho, M., Banerjee, A., Potier, M., ... Striker, G. E. (2005). Glomerular aging in females is a multi-stage reversible process mediated by phenotypic changes in progenitors. American Journal of Pathology, 167(2), 355-363.

Glomerular aging in females is a multi-stage reversible process mediated by phenotypic changes in progenitors. / Feng, Zheng; Plati, Anna Rita; Cheng, Qing Li; Berho, Mariana; Banerjee, Anita; Potier, Mylene; Jy, Wenche; Koff, Andrew; Striker, Liliane J.; Striker, Gary E.

In: American Journal of Pathology, Vol. 167, No. 2, 01.08.2005, p. 355-363.

Research output: Contribution to journalArticle

Feng, Z, Plati, AR, Cheng, QL, Berho, M, Banerjee, A, Potier, M, Jy, W, Koff, A, Striker, LJ & Striker, GE 2005, 'Glomerular aging in females is a multi-stage reversible process mediated by phenotypic changes in progenitors', American Journal of Pathology, vol. 167, no. 2, pp. 355-363.
Feng Z, Plati AR, Cheng QL, Berho M, Banerjee A, Potier M et al. Glomerular aging in females is a multi-stage reversible process mediated by phenotypic changes in progenitors. American Journal of Pathology. 2005 Aug 1;167(2):355-363.
Feng, Zheng ; Plati, Anna Rita ; Cheng, Qing Li ; Berho, Mariana ; Banerjee, Anita ; Potier, Mylene ; Jy, Wenche ; Koff, Andrew ; Striker, Liliane J. ; Striker, Gary E. / Glomerular aging in females is a multi-stage reversible process mediated by phenotypic changes in progenitors. In: American Journal of Pathology. 2005 ; Vol. 167, No. 2. pp. 355-363.
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