Global cerebral ischemia: Synaptic and cognitive dysfunction

Jake T. Neumann, Charles H. Cohan, Kunjan R Dave, Clinton B Wright, Miguel Perez-Pinzon

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Cardiopulmonary arrest is one of the leading causes of death and disability, primarily occurring in the aged population. Numerous global cerebral ischemia animal models induce neuronal damage similar to cardiac arrest. These global cerebral ischemia models range from vessel occlusion to total cessation of cardiac function, both of which have allowed for the investigation of this multifaceted disease and detection of numerous agents that are neuroprotective. Synapses endure a variety of alterations after global cerebral ischemia from the resulting excitotoxicity and have been a major target for neuroprotection; however, neuroprotective agents have proven unsuccessful in clinical trials, as neurological outcomes have not displayed significant improvements in patients. A majority of these neuroprotective agents have specific neuronal targets, where the success of future neuroprotective agents may depend on non-specific targets and numerous cognitive improvements. This review focuses on the different models of global cerebral ischemia, neuronal synaptic alterations, synaptic neuroprotection and behavioral tests that can be used to determine deficits in cognitive function after global cerebral ischemia.

Original languageEnglish
Pages (from-to)20-35
Number of pages16
JournalCurrent Drug Targets
Volume14
Issue number1
StatePublished - Apr 30 2013

Fingerprint

Neuroprotective Agents
Brain Ischemia
Heart Arrest
Animals
Synapses
Cognition
Cause of Death
Animal Models
Cognitive Dysfunction
Clinical Trials
Population
Neuroprotection

Keywords

  • Aging
  • Cardiac arrest
  • Global cerebral ischemia
  • Hippocampus
  • Neuroprotection
  • Synapse

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Clinical Biochemistry
  • Molecular Medicine

Cite this

Global cerebral ischemia : Synaptic and cognitive dysfunction. / Neumann, Jake T.; Cohan, Charles H.; Dave, Kunjan R; Wright, Clinton B; Perez-Pinzon, Miguel.

In: Current Drug Targets, Vol. 14, No. 1, 30.04.2013, p. 20-35.

Research output: Contribution to journalArticle

Neumann, JT, Cohan, CH, Dave, KR, Wright, CB & Perez-Pinzon, M 2013, 'Global cerebral ischemia: Synaptic and cognitive dysfunction', Current Drug Targets, vol. 14, no. 1, pp. 20-35.
Neumann, Jake T. ; Cohan, Charles H. ; Dave, Kunjan R ; Wright, Clinton B ; Perez-Pinzon, Miguel. / Global cerebral ischemia : Synaptic and cognitive dysfunction. In: Current Drug Targets. 2013 ; Vol. 14, No. 1. pp. 20-35.
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