Glioblastoma multiforme of the optic chiasm: A rare case of common pathology

Kirill A. Lyapichev, Amade Bregy, Adrienne Cassel, Chelsea Handfield, Jose Velazquez-Vega, Matthew D. Kay, Gregory Basil, Ricardo J Komotar

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Malignant optic and chiasmatic gliomas are extremely rare, and are classified pathologically as anaplastic astrocytoma or glioblastoma multiforme (GBM). Approximately 40 cases of optic GBM in adults have been reported in the literature, and only five of them were described to originate from the optic chiasm. Case Description: An 82-year-old male patient with a past medical history of diabetes mellitus type 2, melanoma, and bladder cancer presented with gradual vision loss of the left eye in a period of 1 month. After neuro-ophthalmological examination, the decision of thither magnetic resonance imaging (MRI) studies was made. It showed a contrast enhancing mass in the region of the optic chiasm. In this case, imaging study was not enough to establish an accurate diagnosis and a left pterional craniotomy for biopsy and resection of the optic chiasmal mass was performed. After histological evaluation of the mass tissue, the diagnosis of GBM was made. Taking into account the patient′s poor condition and unfavorable prognosis he was moved to inpatient hospice. The patient deceased within 2 months after surgery. Conclusion: Chiasmal GBM is an extremely rare condition where a biopsy is necessary for accurate diagnosis and optimal treatment. Differential diagnosis for such lesions can be very difficult and include demyelinating optic neuritis and non-demyelinating inflammatory optic neuropathy (e.g., sarcoid), vascular lesions (e.g., cavernoma), compressive lesions of the optic apparatus, metastatic malignancy, and primary tumors of the anterior optic pathway. The role of chemotherapy and radiotherapy including novel stereotaxic radiosurgery methods is still unclear and will need to be evaluated.

Original languageEnglish (US)
Pages (from-to)S484-S487
JournalSurgical Neurology International
Volume7
Issue number18
DOIs
StatePublished - Oct 1 2016

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Optic Chiasm
Glioblastoma
Pathology
Optic Nerve Glioma
Biopsy
Optic Neuritis
Optic Nerve Diseases
Hospices
Radiosurgery
Craniotomy
Astrocytoma
Urinary Bladder Neoplasms
Type 2 Diabetes Mellitus
Blood Vessels
Inpatients
Melanoma
Neoplasms
Differential Diagnosis
Radiotherapy
Magnetic Resonance Imaging

Keywords

  • Brain tumor
  • glioblastoma
  • glioma

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Lyapichev, K. A., Bregy, A., Cassel, A., Handfield, C., Velazquez-Vega, J., Kay, M. D., ... Komotar, R. J. (2016). Glioblastoma multiforme of the optic chiasm: A rare case of common pathology. Surgical Neurology International, 7(18), S484-S487. https://doi.org/10.4103/2152-7806.185783

Glioblastoma multiforme of the optic chiasm : A rare case of common pathology. / Lyapichev, Kirill A.; Bregy, Amade; Cassel, Adrienne; Handfield, Chelsea; Velazquez-Vega, Jose; Kay, Matthew D.; Basil, Gregory; Komotar, Ricardo J.

In: Surgical Neurology International, Vol. 7, No. 18, 01.10.2016, p. S484-S487.

Research output: Contribution to journalArticle

Lyapichev, KA, Bregy, A, Cassel, A, Handfield, C, Velazquez-Vega, J, Kay, MD, Basil, G & Komotar, RJ 2016, 'Glioblastoma multiforme of the optic chiasm: A rare case of common pathology', Surgical Neurology International, vol. 7, no. 18, pp. S484-S487. https://doi.org/10.4103/2152-7806.185783
Lyapichev KA, Bregy A, Cassel A, Handfield C, Velazquez-Vega J, Kay MD et al. Glioblastoma multiforme of the optic chiasm: A rare case of common pathology. Surgical Neurology International. 2016 Oct 1;7(18):S484-S487. https://doi.org/10.4103/2152-7806.185783
Lyapichev, Kirill A. ; Bregy, Amade ; Cassel, Adrienne ; Handfield, Chelsea ; Velazquez-Vega, Jose ; Kay, Matthew D. ; Basil, Gregory ; Komotar, Ricardo J. / Glioblastoma multiforme of the optic chiasm : A rare case of common pathology. In: Surgical Neurology International. 2016 ; Vol. 7, No. 18. pp. S484-S487.
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