Glial swelling following human cerebral contusion: An ultrastructural study

R. Bullock, W. L. Maxwell, D. I. Graham, G. M. Teasdale, J. H. Adams

Research output: Contribution to journalArticlepeer-review

147 Scopus citations


The ultrastructural features of cerebral contusion seen three hours to 11 days after head injury were studied in 18 patients undergoing surgery. Massive astrocytic swelling ('cytotoxic' oedema) was seen three hours to three days after injury, maximal in perivascular foot processes, and compressing some of the underlying capillaries. The tight junctions were not disrupted. Neuronal damage was most marked three to 11 days after injury. The pathophysiological mechanisms leading to oedema formation and neuronal degeneration are discussed.

Original languageEnglish (US)
Pages (from-to)427-434
Number of pages8
JournalJournal of Neurology Neurosurgery and Psychiatry
Issue number5
StatePublished - 1991

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health


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