Glial swelling following human cerebral contusion

An ultrastructural study

Ross Bullock, W. L. Maxwell, D. I. Graham, G. M. Teasdale, J. H. Adams

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

The ultrastructural features of cerebral contusion seen three hours to 11 days after head injury were studied in 18 patients undergoing surgery. Massive astrocytic swelling ('cytotoxic' oedema) was seen three hours to three days after injury, maximal in perivascular foot processes, and compressing some of the underlying capillaries. The tight junctions were not disrupted. Neuronal damage was most marked three to 11 days after injury. The pathophysiological mechanisms leading to oedema formation and neuronal degeneration are discussed.

Original languageEnglish
Pages (from-to)427-434
Number of pages8
JournalJournal of Neurology Neurosurgery and Psychiatry
Volume54
Issue number5
StatePublished - Jan 1 1991
Externally publishedYes

Fingerprint

Neuroglia
Edema
Tight Junctions
Wounds and Injuries
Craniocerebral Trauma
Foot
Brain Contusion

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

Cite this

Bullock, R., Maxwell, W. L., Graham, D. I., Teasdale, G. M., & Adams, J. H. (1991). Glial swelling following human cerebral contusion: An ultrastructural study. Journal of Neurology Neurosurgery and Psychiatry, 54(5), 427-434.

Glial swelling following human cerebral contusion : An ultrastructural study. / Bullock, Ross; Maxwell, W. L.; Graham, D. I.; Teasdale, G. M.; Adams, J. H.

In: Journal of Neurology Neurosurgery and Psychiatry, Vol. 54, No. 5, 01.01.1991, p. 427-434.

Research output: Contribution to journalArticle

Bullock, R, Maxwell, WL, Graham, DI, Teasdale, GM & Adams, JH 1991, 'Glial swelling following human cerebral contusion: An ultrastructural study', Journal of Neurology Neurosurgery and Psychiatry, vol. 54, no. 5, pp. 427-434.
Bullock R, Maxwell WL, Graham DI, Teasdale GM, Adams JH. Glial swelling following human cerebral contusion: An ultrastructural study. Journal of Neurology Neurosurgery and Psychiatry. 1991 Jan 1;54(5):427-434.
Bullock, Ross ; Maxwell, W. L. ; Graham, D. I. ; Teasdale, G. M. ; Adams, J. H. / Glial swelling following human cerebral contusion : An ultrastructural study. In: Journal of Neurology Neurosurgery and Psychiatry. 1991 ; Vol. 54, No. 5. pp. 427-434.
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