Glial fibrillary acidic protein and keratin expression by benign and malignant nerve sheath tumors

Mark H. Gray, Andrew Rosenberg, G. Richard Dickersin, Atul K. Bhan

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Formalin-fixed, paraffin-embedded sections of 59 ultrastructurally confirmed nerve sheath tumors (NSTs) that included 27 benign schwannomas, five neurofibromas, and 27 malignant schwannomas were studied by the avidin-biotin-peroxidase complex method using antibodies directed against glial fibrillary acidic protein (GFAP), keratin, S-100 protein, vimentin, and desmin. GFAP was expressed by 33% of the benign schwannomas, 40% of the neurofibromas, and 7% of the malignant schwannomas. Keratin was expressed by 7% of the benign schwannomas and 4% of the malignant schwannomas. S-100 protein was expressed by 100% of the benign NSTs and by 40% of the malignant schwannomas. Vimentin was observed in 100% of the benign NSTs and in 85% of the malignant schwannomas. None of the cases stained for desmin. GFAP and cytokeratin expression could not be predicted on the basis of tumor light microscopy or ultrastructure. These findings are of practical importance in routine surgical pathology, particularly with respect to the differential diagnosis of gliomas located in the central nervous system and in immunohistochemical studies of peripherally located, poorly differentiated neoplasms.

Original languageEnglish
Pages (from-to)1089-1096
Number of pages8
JournalHuman Pathology
Volume20
Issue number11
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

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Type I Keratin
Nerve Sheath Neoplasms
Glial Fibrillary Acidic Protein
Neurilemmoma
Neurofibroma
Desmin
S100 Proteins
Vimentin
Keratins
Surgical Pathology
Avidin
Protein S
Biotin
Glioma
Paraffin
Formaldehyde
Peroxidase
Microscopy
Neoplasms
Differential Diagnosis

Keywords

  • electron microscopy
  • glial fibrillary acidic protein
  • immunohistochemistry
  • keratin
  • nerve sheath tumors
  • S-100 protein
  • vimentin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Glial fibrillary acidic protein and keratin expression by benign and malignant nerve sheath tumors. / Gray, Mark H.; Rosenberg, Andrew; Richard Dickersin, G.; Bhan, Atul K.

In: Human Pathology, Vol. 20, No. 11, 01.01.1989, p. 1089-1096.

Research output: Contribution to journalArticle

Gray, Mark H. ; Rosenberg, Andrew ; Richard Dickersin, G. ; Bhan, Atul K. / Glial fibrillary acidic protein and keratin expression by benign and malignant nerve sheath tumors. In: Human Pathology. 1989 ; Vol. 20, No. 11. pp. 1089-1096.
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