Glaucomatous disease in patients with normal pressure hydrocephalus

Ta Chang, Kuldev Singh

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

PURPOSE: To investigate the relative prevalence of glaucomatous disease in patients with normal pressure hydrocephalus (NPH) compared with age-matched non-NPH controls with hydrocephalus. DESIGN: Case-control study. PARTICIPANTS: Using International Classification of Diseases (ICD-9) codes, we identified the medical records of 72 NPH cases and 72 age-matched controls with hydrocephalus treated at Stanford University Hospital between 1996 and 2007. METHODS: All available electronic medical records were reviewed. The diagnosis of NPH was verified based on clinical presentation, neuroimaging results, and opening pressure on initial access to cerebrospinal fluid space. Glaucoma status was determined based on history and prior medical, laser, or surgical intraocular pressure-lowering therapy. MAIN OUTCOME MEASURE: The proportion of subjects determined as having glaucomatous disease in cases and controls. RESULTS: The prevalence of glaucoma in NPH cases was estimated to be 18.1% in contrast to 5.6% in controls (χ=5.403, P=0.0201). The average age of NPH cases and non-NPH controls was 75.40±13.4 and 73.96±9.92 years (mean±SD), respectively. CONCLUSIONS: We found the prevalence of a glaucoma diagnosis to be 3-fold greater in patients with NPH as compared with age-matched non-NPH controls with hydrocephalus. These findings suggest the possiblity of an association between these 2 neurodegenerative diseases which should be studied prospectively.

Original languageEnglish
Pages (from-to)243-246
Number of pages4
JournalJournal of Glaucoma
Volume18
Issue number3
DOIs
StatePublished - Mar 1 2009
Externally publishedYes

Fingerprint

Normal Pressure Hydrocephalus
Hydrocephalus
International Classification of Diseases
Glaucoma
Pressure
Electronic Health Records
Intraocular Pressure
Neuroimaging
Neurodegenerative Diseases
Medical Records
Cerebrospinal Fluid
Case-Control Studies
Lasers
History

Keywords

  • Glaucoma
  • Hydrocephalus
  • Neural susceptibility
  • Neurodegenerative

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Glaucomatous disease in patients with normal pressure hydrocephalus. / Chang, Ta; Singh, Kuldev.

In: Journal of Glaucoma, Vol. 18, No. 3, 01.03.2009, p. 243-246.

Research output: Contribution to journalArticle

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