Glaucomas: Pseudoexfoliation glaucoma

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

The identity of the material proteins responsible for PXF glaucoma is not known [1]. However, genetic risk factors for the development of PXF material and PXF glaucoma have recently been identified [2]. Single -nucleotide polymorphisms (SNP) in the lysyl oxidase-like 1 (LOXL1) gene are associated with PXF glaucoma in many patient populations, including Scandinavian, Japanese, Australian, and American cohorts [2-9]. LOXL1 is an enzymatic protein important in extracellular matrix metabolism and turnover. Thus, changes in the extracellular matrix of PXF tissues have been hypothesized to be the pathophysiological mechanism responsible for the development of PXF glaucoma [1, 10].

Original languageEnglish (US)
Title of host publicationPearls of Glaucoma Management
PublisherSpringer Berlin Heidelberg
Pages337-343
Number of pages7
ISBN (Print)9783540682387
DOIs
StatePublished - 2010
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Lee, R. K. (2010). Glaucomas: Pseudoexfoliation glaucoma. In Pearls of Glaucoma Management (pp. 337-343). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-540-68240-0_44