Abstract
A life-table analysis of surgical outcomes was performed on the first eye of 155 patients who were enrolled in a pilot study of glaucoma filtering surgery with postoperative subconjunctival 5-fluorouracil (5-FU) injections. The success rates at 1-, 2-, and 3-year intervals were 68, 63, and 63%, respectively, for 88 patients with non-neovascular glaucoma in aphakia; 82, 75, and 75% for 39 patients with non-neovascular glaucoma after unsuccessful filtering surgery; and 68% at each yearly interval for 28 patients with neovascular glaucoma. Complications which resulted from filtering surgery and the 5-FU injections included corneal epithelial defects (55.5%), conjunctival wound leaks (36.8%), suprachoroidal hermorrhage (5.8%), rhegmatogenous retinal detachment (2.6%), endophthalmitis and phthisis (1.9% each), and corneal scarring, late bleb leak, malignant glaucoma, and traction retinal detachment (1.3% each). A Cox Model regression analysis failed to demonstrate a correlation between surgical success and age, race, type of filtering procedure, or total dose of 5-FU received. Postoperative subconjunctival 5-FU may increase the operative success rate for selected patients with a high risk for failure after glaucoma filtering surgery.
Original language | English (US) |
---|---|
Pages (from-to) | 1071-1078 |
Number of pages | 8 |
Journal | Ophthalmology |
Volume | 94 |
Issue number | 9 |
DOIs | |
State | Published - 1987 |
Keywords
- 5-fluorouracil
- filtering surgery
- filtering surgery failure
- glaucoma in aphakia
- glaucoma surgery
- life-table analysis
- neovascular glaucoma
- posterior lip sclerectomy
- trabeculectomy
ASJC Scopus subject areas
- Ophthalmology