Glaucoma Filtering Surgery with 5-Fluorouracil

Edward J. Rockwood, Richard K. Parrish, Dale K. Heuer, Gregory L. Skuta, Elizabeth A. Hodapp, Paul F. Palmberg, Michael G. Gressel, William Feuer

Research output: Contribution to journalArticle

168 Scopus citations

Abstract

A life-table analysis of surgical outcomes was performed on the first eye of 155 patients who were enrolled in a pilot study of glaucoma filtering surgery with postoperative subconjunctival 5-fluorouracil (5-FU) injections. The success rates at 1-, 2-, and 3-year intervals were 68, 63, and 63%, respectively, for 88 patients with non-neovascular glaucoma in aphakia; 82, 75, and 75% for 39 patients with non-neovascular glaucoma after unsuccessful filtering surgery; and 68% at each yearly interval for 28 patients with neovascular glaucoma. Complications which resulted from filtering surgery and the 5-FU injections included corneal epithelial defects (55.5%), conjunctival wound leaks (36.8%), suprachoroidal hermorrhage (5.8%), rhegmatogenous retinal detachment (2.6%), endophthalmitis and phthisis (1.9% each), and corneal scarring, late bleb leak, malignant glaucoma, and traction retinal detachment (1.3% each). A Cox Model regression analysis failed to demonstrate a correlation between surgical success and age, race, type of filtering procedure, or total dose of 5-FU received. Postoperative subconjunctival 5-FU may increase the operative success rate for selected patients with a high risk for failure after glaucoma filtering surgery.

Original languageEnglish (US)
Pages (from-to)1071-1078
Number of pages8
JournalOphthalmology
Volume94
Issue number9
DOIs
StatePublished - Jan 1 1987

Keywords

  • 5-fluorouracil
  • filtering surgery
  • filtering surgery failure
  • glaucoma in aphakia
  • glaucoma surgery
  • life-table analysis
  • neovascular glaucoma
  • posterior lip sclerectomy
  • trabeculectomy

ASJC Scopus subject areas

  • Ophthalmology

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  • Cite this

    Rockwood, E. J., Parrish, R. K., Heuer, D. K., Skuta, G. L., Hodapp, E. A., Palmberg, P. F., Gressel, M. G., & Feuer, W. (1987). Glaucoma Filtering Surgery with 5-Fluorouracil. Ophthalmology, 94(9), 1071-1078. https://doi.org/10.1016/S0161-6420(87)33321-4