Glaucoma, capillaries and pericytes. 4. Beta-adrenergic activation of cultured retinal pericytes

Aino O A Zschauer, E. Barry Davis, Douglas Anderson

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

To characterize the relaxation of pericytes induced by B-adrenergic stimulation, changes in the contractile tone of pericytes were quantified as a change in the wrinkling of an elastic silicone surface on which they were cultured. Isoproterenol produced relaxation of pericytes in a dose-dependent manner over a range of 5 nM to 1 μM. Low concentrations of the nonselective CS-blockers propanolol and timolol blocked the relaxation produced by isoproterenol. The specific β2-adrenergic component of isoproterenol-induced relaxation was shown by blockage with bromoacetyl alprenolol menthane. In contrast, atenolol and betaxolol, as relatively selective β1-adrenergic blockers, had no effect on the isoproterenol-induced relaxation.

Original languageEnglish
Pages (from-to)276-279
Number of pages4
JournalOphthalmologica
Volume210
Issue number5
StatePublished - Sep 1 1996

Fingerprint

Pericytes
Isoproterenol
Glaucoma
Adrenergic Agents
Betaxolol
Alprenolol
Timolol
Adrenergic Antagonists
Atenolol
Silicones
Propranolol

Keywords

  • β-Adrenergic receptors
  • Atenolol
  • Betaxolol
  • Blood flow regulation
  • Capillaries
  • Glaucoma
  • Isoproterenol
  • Pericytes
  • Propranolol
  • Retina
  • Timolol

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Zschauer, A. O. A., Davis, E. B., & Anderson, D. (1996). Glaucoma, capillaries and pericytes. 4. Beta-adrenergic activation of cultured retinal pericytes. Ophthalmologica, 210(5), 276-279.

Glaucoma, capillaries and pericytes. 4. Beta-adrenergic activation of cultured retinal pericytes. / Zschauer, Aino O A; Davis, E. Barry; Anderson, Douglas.

In: Ophthalmologica, Vol. 210, No. 5, 01.09.1996, p. 276-279.

Research output: Contribution to journalArticle

Zschauer, AOA, Davis, EB & Anderson, D 1996, 'Glaucoma, capillaries and pericytes. 4. Beta-adrenergic activation of cultured retinal pericytes', Ophthalmologica, vol. 210, no. 5, pp. 276-279.
Zschauer, Aino O A ; Davis, E. Barry ; Anderson, Douglas. / Glaucoma, capillaries and pericytes. 4. Beta-adrenergic activation of cultured retinal pericytes. In: Ophthalmologica. 1996 ; Vol. 210, No. 5. pp. 276-279.
@article{9b11706f159b4b998ab127ac32c1e8a8,
title = "Glaucoma, capillaries and pericytes. 4. Beta-adrenergic activation of cultured retinal pericytes",
abstract = "To characterize the relaxation of pericytes induced by B-adrenergic stimulation, changes in the contractile tone of pericytes were quantified as a change in the wrinkling of an elastic silicone surface on which they were cultured. Isoproterenol produced relaxation of pericytes in a dose-dependent manner over a range of 5 nM to 1 μM. Low concentrations of the nonselective CS-blockers propanolol and timolol blocked the relaxation produced by isoproterenol. The specific β2-adrenergic component of isoproterenol-induced relaxation was shown by blockage with bromoacetyl alprenolol menthane. In contrast, atenolol and betaxolol, as relatively selective β1-adrenergic blockers, had no effect on the isoproterenol-induced relaxation.",
keywords = "β-Adrenergic receptors, Atenolol, Betaxolol, Blood flow regulation, Capillaries, Glaucoma, Isoproterenol, Pericytes, Propranolol, Retina, Timolol",
author = "Zschauer, {Aino O A} and Davis, {E. Barry} and Douglas Anderson",
year = "1996",
month = "9",
day = "1",
language = "English",
volume = "210",
pages = "276--279",
journal = "Ophthalmologica",
issn = "0030-3755",
publisher = "S. Karger AG",
number = "5",

}

TY - JOUR

T1 - Glaucoma, capillaries and pericytes. 4. Beta-adrenergic activation of cultured retinal pericytes

AU - Zschauer, Aino O A

AU - Davis, E. Barry

AU - Anderson, Douglas

PY - 1996/9/1

Y1 - 1996/9/1

N2 - To characterize the relaxation of pericytes induced by B-adrenergic stimulation, changes in the contractile tone of pericytes were quantified as a change in the wrinkling of an elastic silicone surface on which they were cultured. Isoproterenol produced relaxation of pericytes in a dose-dependent manner over a range of 5 nM to 1 μM. Low concentrations of the nonselective CS-blockers propanolol and timolol blocked the relaxation produced by isoproterenol. The specific β2-adrenergic component of isoproterenol-induced relaxation was shown by blockage with bromoacetyl alprenolol menthane. In contrast, atenolol and betaxolol, as relatively selective β1-adrenergic blockers, had no effect on the isoproterenol-induced relaxation.

AB - To characterize the relaxation of pericytes induced by B-adrenergic stimulation, changes in the contractile tone of pericytes were quantified as a change in the wrinkling of an elastic silicone surface on which they were cultured. Isoproterenol produced relaxation of pericytes in a dose-dependent manner over a range of 5 nM to 1 μM. Low concentrations of the nonselective CS-blockers propanolol and timolol blocked the relaxation produced by isoproterenol. The specific β2-adrenergic component of isoproterenol-induced relaxation was shown by blockage with bromoacetyl alprenolol menthane. In contrast, atenolol and betaxolol, as relatively selective β1-adrenergic blockers, had no effect on the isoproterenol-induced relaxation.

KW - β-Adrenergic receptors

KW - Atenolol

KW - Betaxolol

KW - Blood flow regulation

KW - Capillaries

KW - Glaucoma

KW - Isoproterenol

KW - Pericytes

KW - Propranolol

KW - Retina

KW - Timolol

UR - http://www.scopus.com/inward/record.url?scp=0029813918&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029813918&partnerID=8YFLogxK

M3 - Article

VL - 210

SP - 276

EP - 279

JO - Ophthalmologica

JF - Ophthalmologica

SN - 0030-3755

IS - 5

ER -