Glaucoma, capillaries and pericytes. 4. Beta-adrenergic activation of cultured retinal pericytes

Aino O.A. Zschauer, Barry Davis, Douglas R. Anderson

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

To characterize the relaxation of pericytes induced by B-adrenergic stimulation, changes in the contractile tone of pericytes were quantified as a change in the wrinkling of an elastic silicone surface on which they were cultured. Isoproterenol produced relaxation of pericytes in a dose-dependent manner over a range of 5 nM to 1 μM. Low concentrations of the nonselective CS-blockers propanolol and timolol blocked the relaxation produced by isoproterenol. The specific β2-adrenergic component of isoproterenol-induced relaxation was shown by blockage with bromoacetyl alprenolol menthane. In contrast, atenolol and betaxolol, as relatively selective β1-adrenergic blockers, had no effect on the isoproterenol-induced relaxation.

Original languageEnglish (US)
Pages (from-to)276-279
Number of pages4
JournalOphthalmologica
Volume210
Issue number5
DOIs
StatePublished - Jan 1 1996

Keywords

  • β-Adrenergic receptors
  • Atenolol
  • Betaxolol
  • Blood flow regulation
  • Capillaries
  • Glaucoma
  • Isoproterenol
  • Pericytes
  • Propranolol
  • Retina
  • Timolol

ASJC Scopus subject areas

  • Ophthalmology

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