Glandular secretion of lactoferrin in a patient with neutrophil lactoferrin deficiency

Gordon D. Raphael, Janet L. Davis, Philip C. Fox, Harry L. Malech, John I. Gallin, James N. Baraniuk, Michael A. Kaliner

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Patients with specific granule deficiency (SGD) develop recurrent severe bacterial skin infections. Neutrophils from patients with SGD are deficient in lactoferrin (Lf), an antimicrobial protein commonly found in many mucosal secretions. Unstimulated and stimulated nasal secretions, saliva, and tears were collected from a patient with SGD and from normal control subjects and were analyzed for Lf. The secretions from the patient contained normal values of Lf, suggesting that the glands secrete Lf from a source other than neutrophils. Immunohistochemical staining of normal nasal mucosa demonstrated that Lf is localized within serous submucosal gland cells and that neutrophils are not normally observed in the nasal mucosa. These findings suggest that glandular tissues produce and locally secrete Lf by processes that are independent of neutrophil de granulation.

Original languageEnglish (US)
Pages (from-to)914-919
Number of pages6
JournalThe Journal of Allergy and Clinical Immunology
Volume84
Issue number6 PART 1
DOIs
StatePublished - Dec 1989
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Raphael, G. D., Davis, J. L., Fox, P. C., Malech, H. L., Gallin, J. I., Baraniuk, J. N., & Kaliner, M. A. (1989). Glandular secretion of lactoferrin in a patient with neutrophil lactoferrin deficiency. The Journal of Allergy and Clinical Immunology, 84(6 PART 1), 914-919. https://doi.org/10.1016/0091-6749(89)90389-8