GIGYF2 has no major role in Parkinson genetic etiology in a Belgian population

Bram Meeus, Karen Nuytemans, David Crosiers, Sebastiaan Engelborghs, Philippe Pals, Barbara Pickut, Karin Peeters, Maria Mattheijssens, Ellen Corsmit, Patrick Cras, Peter Paul De Deyn, Jessie Theuns, C. Van Broeckhoven Christine

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Missense mutations were identified in the Grb10-Interacting GYF Protein-2 gene (GIGYF2), located in the chromosomal region 2q36-q37, in familial Parkinson disease (PD) patients of European descent. To determine the contribution of GIGYF2 mutations in an extended (N= 305) Belgian series of both familial and sporadic PD patients, we sequenced all 32 coding and non-coding exons of GIGYF2. In three sporadic PD patients we identified two novel heterozygous missense mutations (c.1907A>G, p.Tyr636Cys and c.2501G>A, p.Arg834Gln), that were absent from control individuals (N= 360). However, since we lack genetic as well as functional data supporting their pathogenic nature, we cannot exclude that these variants are benign polymorphisms. Together, our results do not support a role for GIGYF2 in the genetic etiology of Belgian PD.

Original languageEnglish (US)
Pages (from-to)308-312
Number of pages5
JournalNeurobiology of aging
Volume32
Issue number2
DOIs
StatePublished - Feb 1 2011
Externally publishedYes

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Keywords

  • Chromosome 2
  • GIGYF2
  • Mutations
  • PARK11
  • Parkinson

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Meeus, B., Nuytemans, K., Crosiers, D., Engelborghs, S., Pals, P., Pickut, B., Peeters, K., Mattheijssens, M., Corsmit, E., Cras, P., De Deyn, P. P., Theuns, J., & Van Broeckhoven Christine, C. (2011). GIGYF2 has no major role in Parkinson genetic etiology in a Belgian population. Neurobiology of aging, 32(2), 308-312. https://doi.org/10.1016/j.neurobiolaging.2009.02.016