Giant cell tumor of the larynx: A case of malignant sarcomatous transformation

Richard J. Vivero, Sandeep P. Dave, Carmen R. Gomez, Donald T. Weed

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

We report what is to the best of our knowledge the first case of malignant transformation of a giant cell tumor of the larynx. The patient, a 34-year-old man, presented to our tertiary care university teaching hospital where he underwent hemilaryngopharyngectomy with radial forearm free flap reconstruction and 11 of 15 cycles of chemotherapy. He remained disease-free at approximately 6 years and 4 months of follow-up. The patient is decannulated and continues to have a good voice with excellent quality of life to this day. We discuss the patient's clinical course and subsequent treatment within the context of a review of the current literature regarding this disease entity. Our experience demonstrates that giant cell tumor of the larynx may present as a malignant neoplasm without adversely affecting the patient's prognosis when treated aggressively with surgical resection and adjunct chemotherapy.

Original languageEnglish (US)
Article numberE59
JournalEar, Nose and Throat Journal
Volume92
Issue number6
StatePublished - Jun 1 2013

ASJC Scopus subject areas

  • Otorhinolaryngology

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