Getting Closer to an Effective Intervention of Ischemic Stroke: The Big Promise of Stem Cell

Deepaneeta Sarmah; Harpreet Kaur; Jackson Saraf; Kanta Pravalika; Avirag Goswami; Kiran Kalia; Anupom Borah; Xin Wang; Kunjan R. Dave; Dileep R. Yavagal; Pallab Bhattacharya

doi:10.1007/s12975-017-0580-0

Getting Closer to an Effective Intervention of Ischemic Stroke: The Big Promise of Stem Cell

Deepaneeta Sarmah, Harpreet Kaur, Jackson Saraf, Kanta Pravalika, Avirag Goswami, Kiran Kalia, Anupom Borah, Xin Wang, Kunjan R. Dave, Dileep R. Yavagal, Pallab Bhattacharya

Neurology

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

Stem cell therapy for ischemic stroke has widely been explored. Results from both preclinical and clinical studies have immensely supported the judicious use of stem cells as therapy. These provide an attractive means for preserving and replacing the damaged brain tissues following an ischemic attack. Since the past few years, researchers have used various types of stem cells to replenish insulted neuronal and glial cells in neurological disorders. In the present review, we discuss different types of stem cells employed for the treatment of ischemic stroke and mechanisms and challenges these cells face once introduced into the living system. Further, we also present different ways to maneuver and overcome challenges to translate the advances made at the preclinical level to clinics.

Original language	English (US)
Pages (from-to)	356-374
Number of pages	19
Journal	Translational stroke research
Volume	9
Issue number	4
DOIs	https://doi.org/10.1007/s12975-017-0580-0
State	Published - Aug 1 2018

Keywords

Cell engineering
Clinical
Ischemic stroke
Neuroprotection
Preclinical
Stem cells

ASJC Scopus subject areas

Neuroscience(all)
Clinical Neurology
Cardiology and Cardiovascular Medicine

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10.1007/s12975-017-0580-0

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Getting Closer to an Effective Intervention of Ischemic Stroke : The Big Promise of Stem Cell. / Sarmah, Deepaneeta; Kaur, Harpreet; Saraf, Jackson; Pravalika, Kanta; Goswami, Avirag; Kalia, Kiran; Borah, Anupom; Wang, Xin; Dave, Kunjan R.; Yavagal, Dileep R.; Bhattacharya, Pallab.

In: Translational stroke research, Vol. 9, No. 4, 01.08.2018, p. 356-374.

Research output: Contribution to journal › Review article › peer-review

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abstract = "Stem cell therapy for ischemic stroke has widely been explored. Results from both preclinical and clinical studies have immensely supported the judicious use of stem cells as therapy. These provide an attractive means for preserving and replacing the damaged brain tissues following an ischemic attack. Since the past few years, researchers have used various types of stem cells to replenish insulted neuronal and glial cells in neurological disorders. In the present review, we discuss different types of stem cells employed for the treatment of ischemic stroke and mechanisms and challenges these cells face once introduced into the living system. Further, we also present different ways to maneuver and overcome challenges to translate the advances made at the preclinical level to clinics.",

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author = "Deepaneeta Sarmah and Harpreet Kaur and Jackson Saraf and Kanta Pravalika and Avirag Goswami and Kiran Kalia and Anupom Borah and Xin Wang and Dave, {Kunjan R.} and Yavagal, {Dileep R.} and Pallab Bhattacharya",

note = "Funding Information: The authors acknowledge the Department of Science and Technology (DST), Govt. of India, for their financial support through grant (SB/YS/LS-196/2014), International Society for Neurochemistry (ISN) Return Home grant, Department of Pharmaceuticals, Ministry of Chemical and Fertilizers, Govt of India and National Institute of Pharmaceutical Education and Research (NIPER) Ahmedabad, Gandhinagar, India. The authors also want to express their thanks to Boston Children?s Hospital, Harvard Medical School, Boston, MA, USA and the Director, NIPER Ahmedabad, for providing necessary support. The authors declare that they have no conflict of interest. Publisher Copyright: {\textcopyright} 2017, Springer Science+Business Media, LLC.",

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Getting Closer to an Effective Intervention of Ischemic Stroke: The Big Promise of Stem Cell

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Keywords

ASJC Scopus subject areas

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