Getting Closer to an Effective Intervention of Ischemic Stroke: The Big Promise of Stem Cell

Deepaneeta Sarmah, Harpreet Kaur, Jackson Saraf, Kanta Pravalika, Avirag Goswami, Kiran Kalia, Anupom Borah, Xin Wang, Kunjan R. Dave, Dileep R. Yavagal, Pallab Bhattacharya

Research output: Contribution to journalReview article

24 Scopus citations

Abstract

Stem cell therapy for ischemic stroke has widely been explored. Results from both preclinical and clinical studies have immensely supported the judicious use of stem cells as therapy. These provide an attractive means for preserving and replacing the damaged brain tissues following an ischemic attack. Since the past few years, researchers have used various types of stem cells to replenish insulted neuronal and glial cells in neurological disorders. In the present review, we discuss different types of stem cells employed for the treatment of ischemic stroke and mechanisms and challenges these cells face once introduced into the living system. Further, we also present different ways to maneuver and overcome challenges to translate the advances made at the preclinical level to clinics.

Original languageEnglish (US)
Pages (from-to)356-374
Number of pages19
JournalTranslational stroke research
Volume9
Issue number4
DOIs
StatePublished - Aug 1 2018

Keywords

  • Cell engineering
  • Clinical
  • Ischemic stroke
  • Neuroprotection
  • Preclinical
  • Stem cells

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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    Sarmah, D., Kaur, H., Saraf, J., Pravalika, K., Goswami, A., Kalia, K., Borah, A., Wang, X., Dave, K. R., Yavagal, D. R., & Bhattacharya, P. (2018). Getting Closer to an Effective Intervention of Ischemic Stroke: The Big Promise of Stem Cell. Translational stroke research, 9(4), 356-374. https://doi.org/10.1007/s12975-017-0580-0