Abstract
Primordial germ cells (PGCs) represent the only precursor stem cell population that normally gives rise to the gametes. For this reason, PGCs have been called the "stem cells of the species" and are prime examples of a normal totipotent state (Wylie, 1999. Cell 96 (2): 165-174). PGCs represent a remarkable lineage that will differentiate into highly specialized cells, either oocytes or sperm, yet also retain the ability to generate a complete new individual. Thus, a fundamental question in developmental and stem cell biology is how PGCs differentiate while retaining the potential for totipotency in contrast to somatic cells that become fate-restricted. In this chapter, we will review what is known about how Xenopus sets aside its germ-cell lineage.
| Original language | English (US) |
|---|---|
| Title of host publication | Xenopus Development |
| Publisher | Wiley Blackwell |
| Pages | 75-100 |
| Number of pages | 26 |
| ISBN (Print) | 9781118492833, 9781118492819 |
| DOIs | |
| State | Published - Jun 3 2014 |
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Keywords
- Germ plasm
- nanos
- Primordial germ cells
- Totipotency
- Transcriptional repression
- Translational control
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Germ-Cell Specification in Xenopus. / King, Mary Lou L.
Xenopus Development. Wiley Blackwell, 2014. p. 75-100.Research output: Chapter in Book/Report/Conference proceeding › Chapter
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TY - CHAP
T1 - Germ-Cell Specification in Xenopus
AU - King, Mary Lou L
PY - 2014/6/3
Y1 - 2014/6/3
N2 - Primordial germ cells (PGCs) represent the only precursor stem cell population that normally gives rise to the gametes. For this reason, PGCs have been called the "stem cells of the species" and are prime examples of a normal totipotent state (Wylie, 1999. Cell 96 (2): 165-174). PGCs represent a remarkable lineage that will differentiate into highly specialized cells, either oocytes or sperm, yet also retain the ability to generate a complete new individual. Thus, a fundamental question in developmental and stem cell biology is how PGCs differentiate while retaining the potential for totipotency in contrast to somatic cells that become fate-restricted. In this chapter, we will review what is known about how Xenopus sets aside its germ-cell lineage.
AB - Primordial germ cells (PGCs) represent the only precursor stem cell population that normally gives rise to the gametes. For this reason, PGCs have been called the "stem cells of the species" and are prime examples of a normal totipotent state (Wylie, 1999. Cell 96 (2): 165-174). PGCs represent a remarkable lineage that will differentiate into highly specialized cells, either oocytes or sperm, yet also retain the ability to generate a complete new individual. Thus, a fundamental question in developmental and stem cell biology is how PGCs differentiate while retaining the potential for totipotency in contrast to somatic cells that become fate-restricted. In this chapter, we will review what is known about how Xenopus sets aside its germ-cell lineage.
KW - Germ plasm
KW - nanos
KW - Primordial germ cells
KW - Totipotency
KW - Transcriptional repression
KW - Translational control
UR - http://www.scopus.com/inward/record.url?scp=84927576369&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84927576369&partnerID=8YFLogxK
U2 - 10.1002/9781118492833.ch5
DO - 10.1002/9781118492833.ch5
M3 - Chapter
SN - 9781118492833
SN - 9781118492819
SP - 75
EP - 100
BT - Xenopus Development
PB - Wiley Blackwell
ER -