Gentamicin-resistant pseudomonal infection. Rationale for a redefinition of ophthalmic antimicrobial sensitivities

L. D. Ormerod, P. N R Heseltine, Eduardo C Alfonso, M. I. Becker, K. R. Kenyon, G. Baerveldt, R. E. Smith

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Eight pseudomonal species were involved in 106 invasive infections of the eye; all were community acquired. Eighteen percent of the total and 9% of the Pseudomonas aeruginosa strains were gentamicin resistant, as defined using conventional criteria. All 10 cases of 'resistant' pseudomonal (nine P. aeruginosa) keratitis responded satisfactorily to treatment with gentamicin. The resistance breakpoint (defined by safe serum levels in parenteral therapy) for most P. aeruginosa is much lower than ocular gentamicin levels achievable by optimal local application. We argue for a specific ophthalmologic definition of antibiotic resistance in infections of the cornea and external eye. MIC quantitative determinations of ocular isolates would provide more useful information to ophthalmologists than conventional qualitative disc sensitivity testing.

Original languageEnglish
Pages (from-to)195-199
Number of pages5
JournalCornea
Volume8
Issue number3
StatePublished - Jan 1 1989
Externally publishedYes

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Gentamicins
Pseudomonas aeruginosa
Infection
Eye Infections
Keratitis
Microbial Drug Resistance
Cornea
Therapeutics
Serum

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Ormerod, L. D., Heseltine, P. N. R., Alfonso, E. C., Becker, M. I., Kenyon, K. R., Baerveldt, G., & Smith, R. E. (1989). Gentamicin-resistant pseudomonal infection. Rationale for a redefinition of ophthalmic antimicrobial sensitivities. Cornea, 8(3), 195-199.

Gentamicin-resistant pseudomonal infection. Rationale for a redefinition of ophthalmic antimicrobial sensitivities. / Ormerod, L. D.; Heseltine, P. N R; Alfonso, Eduardo C; Becker, M. I.; Kenyon, K. R.; Baerveldt, G.; Smith, R. E.

In: Cornea, Vol. 8, No. 3, 01.01.1989, p. 195-199.

Research output: Contribution to journalArticle

Ormerod, LD, Heseltine, PNR, Alfonso, EC, Becker, MI, Kenyon, KR, Baerveldt, G & Smith, RE 1989, 'Gentamicin-resistant pseudomonal infection. Rationale for a redefinition of ophthalmic antimicrobial sensitivities', Cornea, vol. 8, no. 3, pp. 195-199.
Ormerod LD, Heseltine PNR, Alfonso EC, Becker MI, Kenyon KR, Baerveldt G et al. Gentamicin-resistant pseudomonal infection. Rationale for a redefinition of ophthalmic antimicrobial sensitivities. Cornea. 1989 Jan 1;8(3):195-199.
Ormerod, L. D. ; Heseltine, P. N R ; Alfonso, Eduardo C ; Becker, M. I. ; Kenyon, K. R. ; Baerveldt, G. ; Smith, R. E. / Gentamicin-resistant pseudomonal infection. Rationale for a redefinition of ophthalmic antimicrobial sensitivities. In: Cornea. 1989 ; Vol. 8, No. 3. pp. 195-199.
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