Sixty infants with urinary-tract infections were treated with gentamicin in a total daily dose of 5 mg/kg; 20 infants received the drug twice daily, and 40 received it thrice daily. The concentration of drug in the blood never exceeded 6 µg/ml, but it was higher and lasted longer in infants given the drug twice daily. Seventy-five percent of the administered dose was excreted in the urine. Although the level of urea nitrogen in blood rose in eight infants on the fifth day of treatment, by the seventh day, all infants had normal levels. No other toxic effects were observed.
|Original language||English (US)|
|Journal||Journal of Infectious Diseases|
|State||Published - 1971|
ASJC Scopus subject areas
- Infectious Diseases
- Immunology and Allergy