Genomic Signatures of a Global Fitness Index in a Multi-Ethnic Cohort of Women

Evadnie Rampersaud, Lubov Nathanson, Jeffrey Farmer, Karyn Meshbane, Richard L. Belton, Amy Dressen, Michael Cuccaro, Anthony Musto, Sylvia Daunert, Sapna K Deo, Natasha Hudson, Jeffery M Vance, David M Seo, Armando J Mendez, Derek M Dykxhoorn, Margaret A Pericak-Vance, Pascal Goldschmidt-Clermont

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The rates of obesity and sedentary lifestyle are on a dramatic incline, with associated detrimental health effects among women in particular. Although exercise prescriptions are useful for overcoming these problems, success can be hampered by differential responsiveness among individuals in cardiovascular fitness indices (i.e. improvements in strength, lipids, VO2max). Genomic factors appear to play an important role in determining this inter-individual variation. We performed microarray analyses on mRNA in whole blood from 60 sedentary women from a multi-ethnic cohort who underwent 12 weeks of exercise, to identify gene subsets that were differentially expressed between individuals who experienced the greatest and least improvements in fitness. We identified 43 transcripts in 39 unique genes (FDR<10%; FC>1.5) whose expression increased the most in "high" versus "low" pre-menopausal female responders. These 39 genes were enriched in six biological pathways, including oxidative phosphorylation (p = 8.08 × 10-3). Several of the 39 genes (i.e. TIGD7, UQCRH, PSMA6, WDR12, TFB2M, USP15) have previously reported associations with fitness-related phenotypes. In summary, we identified gene signatures based on mRNA analysis that define responsiveness to exercise in a largely minority-based female cohort. Importantly, this study validates several genes/pathways previously associated with exercise responsiveness and extends these findings with additional novel genes.

Original languageEnglish
Pages (from-to)147-157
Number of pages11
JournalAnnals of Human Genetics
Volume77
Issue number2
DOIs
StatePublished - Mar 1 2013

Fingerprint

Genes
Exercise
Sedentary Lifestyle
Messenger RNA
Oxidative Phosphorylation
Microarray Analysis
Prescriptions
Obesity
Phenotype
Lipids
Health

Keywords

  • Bioinformatics
  • Cardiovascular
  • Exercise
  • Genomics
  • Responsiveness

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Rampersaud, E., Nathanson, L., Farmer, J., Meshbane, K., Belton, R. L., Dressen, A., ... Goldschmidt-Clermont, P. (2013). Genomic Signatures of a Global Fitness Index in a Multi-Ethnic Cohort of Women. Annals of Human Genetics, 77(2), 147-157. https://doi.org/10.1111/ahg.12006

Genomic Signatures of a Global Fitness Index in a Multi-Ethnic Cohort of Women. / Rampersaud, Evadnie; Nathanson, Lubov; Farmer, Jeffrey; Meshbane, Karyn; Belton, Richard L.; Dressen, Amy; Cuccaro, Michael; Musto, Anthony; Daunert, Sylvia; Deo, Sapna K; Hudson, Natasha; Vance, Jeffery M; Seo, David M; Mendez, Armando J; Dykxhoorn, Derek M; Pericak-Vance, Margaret A; Goldschmidt-Clermont, Pascal.

In: Annals of Human Genetics, Vol. 77, No. 2, 01.03.2013, p. 147-157.

Research output: Contribution to journalArticle

Rampersaud, E, Nathanson, L, Farmer, J, Meshbane, K, Belton, RL, Dressen, A, Cuccaro, M, Musto, A, Daunert, S, Deo, SK, Hudson, N, Vance, JM, Seo, DM, Mendez, AJ, Dykxhoorn, DM, Pericak-Vance, MA & Goldschmidt-Clermont, P 2013, 'Genomic Signatures of a Global Fitness Index in a Multi-Ethnic Cohort of Women', Annals of Human Genetics, vol. 77, no. 2, pp. 147-157. https://doi.org/10.1111/ahg.12006
Rampersaud E, Nathanson L, Farmer J, Meshbane K, Belton RL, Dressen A et al. Genomic Signatures of a Global Fitness Index in a Multi-Ethnic Cohort of Women. Annals of Human Genetics. 2013 Mar 1;77(2):147-157. https://doi.org/10.1111/ahg.12006
Rampersaud, Evadnie ; Nathanson, Lubov ; Farmer, Jeffrey ; Meshbane, Karyn ; Belton, Richard L. ; Dressen, Amy ; Cuccaro, Michael ; Musto, Anthony ; Daunert, Sylvia ; Deo, Sapna K ; Hudson, Natasha ; Vance, Jeffery M ; Seo, David M ; Mendez, Armando J ; Dykxhoorn, Derek M ; Pericak-Vance, Margaret A ; Goldschmidt-Clermont, Pascal. / Genomic Signatures of a Global Fitness Index in a Multi-Ethnic Cohort of Women. In: Annals of Human Genetics. 2013 ; Vol. 77, No. 2. pp. 147-157.
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