Genomic instability and tumor stem cells

James M. Grichnik

Research output: Contribution to journalComment/debate

20 Scopus citations


Wang et al. point to the existance of a common progenitor tumor stem cell that gives rise to genomically unstable progeny in malignant melanoma. Although it is not known what creates this genomic instability, given the presence of testis antigens in melanoma, it is tempting to speculate that it is caused by a collision of meiotic and mitotic pathways.

Original languageEnglish (US)
Pages (from-to)1214-1216
Number of pages3
JournalJournal of Investigative Dermatology
Issue number6
StatePublished - Jun 2006


ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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