Genomic and proteomic profiles of heart disease

Howard Prentice, Keith A Webster

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Genomics and proteomics are becoming powerful tools for profiling diseased states. The human genome is estimated to encode 30,000 to 40,000 genes, generating more than 100,000 functionally distinct proteins. Microarray data are available for multiple models of heart disease as well as for diseased and failing human hearts. Similarly, two-dimensional gel data banks of normal and diseased myocardium from multiple species are published and are available on the Internet. The combined technologies are beginning to provide new insights into the causes and pathways of cardiac dysfunction. This article reviews the novel findings that have been acquired from genomic and proteomic screens of diseased hearts in animal models and humans.

Original languageEnglish
Pages (from-to)282-288
Number of pages7
JournalTrends in Cardiovascular Medicine
Volume14
Issue number7
DOIs
StatePublished - Oct 1 2004

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Proteomics
Heart Diseases
Human Genome
Genomics
Internet
Myocardium
Animal Models
Gels
Databases
Technology
Genes
Proteins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Genomic and proteomic profiles of heart disease. / Prentice, Howard; Webster, Keith A.

In: Trends in Cardiovascular Medicine, Vol. 14, No. 7, 01.10.2004, p. 282-288.

Research output: Contribution to journalArticle

Prentice, Howard ; Webster, Keith A. / Genomic and proteomic profiles of heart disease. In: Trends in Cardiovascular Medicine. 2004 ; Vol. 14, No. 7. pp. 282-288.
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