Genome-wide scan for Parkinson's disease: The GenePD study

A. L. DeStefano, L. I. Golbe, M. H. Mark, A. M. Lazzarini, N. E. Maher, M. Saint-Hilaire, R. G. Feldman, M. Guttman, R. L. Watts, O. Suchowersky, A. L. Lafontaine, N. Labelle, M. F. Lew, C. H. Waters, J. H. Growdon, Carlos Singer, L. J. Currie, G. F. Wooten, P. Vieregge, P. P. PramstallerC. Klein, J. P. Hubble, M. Stacy, E. Montgomery, M. E. MacDonald, J. F. Gusella, R. H. Myers

Research output: Contribution to journalArticle

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Abstract

A genome-wide scan for idiopathic PD in a sample of 113 PD-affected sibling pairs is reported. Suggestive evidence for linkage was found for chromosomes 1 (214 cM, lod = 1.20), 9 (136 cM, lod = 1.30), 10 (88 cM, lod = 1.07), and 16 (114 cM, lod = 0.93). The chromosome 9 region overlaps the genes for dopamine β-hydroxylase and torsion dystonia. Although no strong evidence for linkage was found for any locus, these results may be of value in comparison with similar studies by others.

Original languageEnglish
Pages (from-to)1124-1126
Number of pages3
JournalNeurology
Volume57
Issue number6
StatePublished - Sep 25 2001

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Dystonia Musculorum Deformans
Chromosomes, Human, Pair 9
Chromosomes, Human, Pair 1
Mixed Function Oxygenases
Parkinson Disease
Dopamine
Genome
Genes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

DeStefano, A. L., Golbe, L. I., Mark, M. H., Lazzarini, A. M., Maher, N. E., Saint-Hilaire, M., ... Myers, R. H. (2001). Genome-wide scan for Parkinson's disease: The GenePD study. Neurology, 57(6), 1124-1126.

Genome-wide scan for Parkinson's disease : The GenePD study. / DeStefano, A. L.; Golbe, L. I.; Mark, M. H.; Lazzarini, A. M.; Maher, N. E.; Saint-Hilaire, M.; Feldman, R. G.; Guttman, M.; Watts, R. L.; Suchowersky, O.; Lafontaine, A. L.; Labelle, N.; Lew, M. F.; Waters, C. H.; Growdon, J. H.; Singer, Carlos; Currie, L. J.; Wooten, G. F.; Vieregge, P.; Pramstaller, P. P.; Klein, C.; Hubble, J. P.; Stacy, M.; Montgomery, E.; MacDonald, M. E.; Gusella, J. F.; Myers, R. H.

In: Neurology, Vol. 57, No. 6, 25.09.2001, p. 1124-1126.

Research output: Contribution to journalArticle

DeStefano, AL, Golbe, LI, Mark, MH, Lazzarini, AM, Maher, NE, Saint-Hilaire, M, Feldman, RG, Guttman, M, Watts, RL, Suchowersky, O, Lafontaine, AL, Labelle, N, Lew, MF, Waters, CH, Growdon, JH, Singer, C, Currie, LJ, Wooten, GF, Vieregge, P, Pramstaller, PP, Klein, C, Hubble, JP, Stacy, M, Montgomery, E, MacDonald, ME, Gusella, JF & Myers, RH 2001, 'Genome-wide scan for Parkinson's disease: The GenePD study', Neurology, vol. 57, no. 6, pp. 1124-1126.
DeStefano AL, Golbe LI, Mark MH, Lazzarini AM, Maher NE, Saint-Hilaire M et al. Genome-wide scan for Parkinson's disease: The GenePD study. Neurology. 2001 Sep 25;57(6):1124-1126.
DeStefano, A. L. ; Golbe, L. I. ; Mark, M. H. ; Lazzarini, A. M. ; Maher, N. E. ; Saint-Hilaire, M. ; Feldman, R. G. ; Guttman, M. ; Watts, R. L. ; Suchowersky, O. ; Lafontaine, A. L. ; Labelle, N. ; Lew, M. F. ; Waters, C. H. ; Growdon, J. H. ; Singer, Carlos ; Currie, L. J. ; Wooten, G. F. ; Vieregge, P. ; Pramstaller, P. P. ; Klein, C. ; Hubble, J. P. ; Stacy, M. ; Montgomery, E. ; MacDonald, M. E. ; Gusella, J. F. ; Myers, R. H. / Genome-wide scan for Parkinson's disease : The GenePD study. In: Neurology. 2001 ; Vol. 57, No. 6. pp. 1124-1126.
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AU - Maher, N. E.

AU - Saint-Hilaire, M.

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AU - Currie, L. J.

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AU - Vieregge, P.

AU - Pramstaller, P. P.

AU - Klein, C.

AU - Hubble, J. P.

AU - Stacy, M.

AU - Montgomery, E.

AU - MacDonald, M. E.

AU - Gusella, J. F.

AU - Myers, R. H.

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