Genome-wide Linkage Screen in Familial Parkinson Disease Identifies Loci on Chromosomes 3 and 18

Xiaoyi Gao, Eden R. Martin, Yutao Liu, Gregory Mayhew, Jeffery M. Vance, William K. Scott

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Parkinson disease (PD) is a complex, multifactorial neurodegenerative disease with substantial evidence for genetic risk factors. We conducted a genome-wide linkage screen of 5824 single-nucleotide polymorphisms in 278 families of European, non-Hispanic descent to localize regions that harbor susceptibility loci for PD. By using parametric and nonparametric linkage analyses and allowing for genetic heterogeneity among families, we found two loci for PD. Significant evidence for linkage was detected on chromosome 18q11 (maximum lod score [MLOD] = 4.1) and suggestive evidence for linkage was obtained on chromosome 3q25 (MLOD = 2.5). These results were strongest in families not previously screened for linkage, and simulation studies suggest that these findings are likely due to locus heterogeneity rather than random statistical error. The finding of two loci (one highly statistically significant) suggests that additional PD susceptibility genes might be identified through targeted candidate gene studies in these regions.

Original languageEnglish (US)
Pages (from-to)499-504
Number of pages6
JournalAmerican journal of human genetics
Volume84
Issue number4
DOIs
StatePublished - Apr 10 2009

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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