Genetics of type 1 diabetes

Maria J. Redondo, Andrea K. Steck, Alberto Pugliese

Research output: Contribution to journalReview article

32 Scopus citations

Abstract

Type 1 diabetes (T1D) results from immune-mediated loss of pancreatic beta cells leading to insulin deficiency. It is the most common form of diabetes in children, and its incidence is on the rise. This article reviews the current knowledge on the genetics of T1D. In particular, we discuss the influence of HLA and non-HLA genes on T1D risk and disease progression through the preclinical stages of the disease, and the development of genetic scores that can be applied to disease prediction. Racial/ethnic differences, challenges and future directions in the genetics of T1D are also discussed.

Original languageEnglish (US)
Pages (from-to)346-353
Number of pages8
JournalPediatric Diabetes
Volume19
Issue number3
DOIs
StatePublished - May 2018

Keywords

  • HLA
  • epidemiology
  • etiology
  • genetics
  • type 1 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism

Fingerprint Dive into the research topics of 'Genetics of type 1 diabetes'. Together they form a unique fingerprint.

  • Cite this