Genetics of type 1 diabetes

Maria J. Redondo, Andrea K. Steck, Alberto Pugliese

Research output: Contribution to journalReview articlepeer-review

70 Scopus citations


Type 1 diabetes (T1D) results from immune-mediated loss of pancreatic beta cells leading to insulin deficiency. It is the most common form of diabetes in children, and its incidence is on the rise. This article reviews the current knowledge on the genetics of T1D. In particular, we discuss the influence of HLA and non-HLA genes on T1D risk and disease progression through the preclinical stages of the disease, and the development of genetic scores that can be applied to disease prediction. Racial/ethnic differences, challenges and future directions in the genetics of T1D are also discussed.

Original languageEnglish (US)
Pages (from-to)346-353
Number of pages8
JournalPediatric Diabetes
Issue number3
StatePublished - May 2018


  • HLA
  • epidemiology
  • etiology
  • genetics
  • type 1 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism


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