Genetics of pancreatic cyst-cancer progression

Standing on the shoulders of giants

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Purpose of review: Pancreatic cancer, despite years of study and some progress, presents with a grim prognosis in almost all cases. In the current review, we have discussed recent studies that have attempted to decipher the genetic makeup of pancreatic ductal adenocarcinoma and preneoplastic pancreatic cystic neoplasms. Recent findings: With the advent of high throughput sequencing, the genetic code of pancreatic cancer is beginning to unravel and this new-found information heralds an era of precision cancer care where treatment will be guided by the genetic code of the neoplasm. Results from these studies have pointed towards the complexity and heterogeneity of the pancreatic cancer genome, provided avenues to "tailor therapy" based as well as shed light on progression of preneoplastic pancreatic neoplasms into full blown invasive pancreatic ductal adenocarcinoma. Summary: While this progress has made us closer to the model of precision medicine, significant obstacles need to be overcome to use this new-found information to change the way we manage patients with pancreatic cancer.

Original languageEnglish (US)
Pages (from-to)404-410
Number of pages7
JournalCurrent Opinion in Gastroenterology
Volume33
Issue number5
DOIs
StatePublished - Sep 1 2017

Fingerprint

Pancreatic Cyst
Pancreatic Neoplasms
Genetic Code
Adenocarcinoma
Precision Medicine
Neoplasms
Genome
Therapeutics

Keywords

  • cystic neoplasms
  • genome
  • intraductal papillary mucinous neoplasm
  • KRAS
  • MCN
  • mutations
  • pancreatic cancer
  • RNF43
  • TP53
  • whole genome sequencing

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Genetics of pancreatic cyst-cancer progression : Standing on the shoulders of giants. / Giri, Bhuwan; Sethi, Vrishketan; Dudeja, Vikas; Banerjee, Sulagna; Livingstone, Alan; Saluja, Ashok.

In: Current Opinion in Gastroenterology, Vol. 33, No. 5, 01.09.2017, p. 404-410.

Research output: Contribution to journalReview article

@article{5321caba17d142278eaefaef651f3e26,
title = "Genetics of pancreatic cyst-cancer progression: Standing on the shoulders of giants",
abstract = "Purpose of review: Pancreatic cancer, despite years of study and some progress, presents with a grim prognosis in almost all cases. In the current review, we have discussed recent studies that have attempted to decipher the genetic makeup of pancreatic ductal adenocarcinoma and preneoplastic pancreatic cystic neoplasms. Recent findings: With the advent of high throughput sequencing, the genetic code of pancreatic cancer is beginning to unravel and this new-found information heralds an era of precision cancer care where treatment will be guided by the genetic code of the neoplasm. Results from these studies have pointed towards the complexity and heterogeneity of the pancreatic cancer genome, provided avenues to {"}tailor therapy{"} based as well as shed light on progression of preneoplastic pancreatic neoplasms into full blown invasive pancreatic ductal adenocarcinoma. Summary: While this progress has made us closer to the model of precision medicine, significant obstacles need to be overcome to use this new-found information to change the way we manage patients with pancreatic cancer.",
keywords = "cystic neoplasms, genome, intraductal papillary mucinous neoplasm, KRAS, MCN, mutations, pancreatic cancer, RNF43, TP53, whole genome sequencing",
author = "Bhuwan Giri and Vrishketan Sethi and Vikas Dudeja and Sulagna Banerjee and Alan Livingstone and Ashok Saluja",
year = "2017",
month = "9",
day = "1",
doi = "10.1097/MOG.0000000000000382",
language = "English (US)",
volume = "33",
pages = "404--410",
journal = "Current Opinion in Gastroenterology",
issn = "0267-1379",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Genetics of pancreatic cyst-cancer progression

T2 - Standing on the shoulders of giants

AU - Giri, Bhuwan

AU - Sethi, Vrishketan

AU - Dudeja, Vikas

AU - Banerjee, Sulagna

AU - Livingstone, Alan

AU - Saluja, Ashok

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Purpose of review: Pancreatic cancer, despite years of study and some progress, presents with a grim prognosis in almost all cases. In the current review, we have discussed recent studies that have attempted to decipher the genetic makeup of pancreatic ductal adenocarcinoma and preneoplastic pancreatic cystic neoplasms. Recent findings: With the advent of high throughput sequencing, the genetic code of pancreatic cancer is beginning to unravel and this new-found information heralds an era of precision cancer care where treatment will be guided by the genetic code of the neoplasm. Results from these studies have pointed towards the complexity and heterogeneity of the pancreatic cancer genome, provided avenues to "tailor therapy" based as well as shed light on progression of preneoplastic pancreatic neoplasms into full blown invasive pancreatic ductal adenocarcinoma. Summary: While this progress has made us closer to the model of precision medicine, significant obstacles need to be overcome to use this new-found information to change the way we manage patients with pancreatic cancer.

AB - Purpose of review: Pancreatic cancer, despite years of study and some progress, presents with a grim prognosis in almost all cases. In the current review, we have discussed recent studies that have attempted to decipher the genetic makeup of pancreatic ductal adenocarcinoma and preneoplastic pancreatic cystic neoplasms. Recent findings: With the advent of high throughput sequencing, the genetic code of pancreatic cancer is beginning to unravel and this new-found information heralds an era of precision cancer care where treatment will be guided by the genetic code of the neoplasm. Results from these studies have pointed towards the complexity and heterogeneity of the pancreatic cancer genome, provided avenues to "tailor therapy" based as well as shed light on progression of preneoplastic pancreatic neoplasms into full blown invasive pancreatic ductal adenocarcinoma. Summary: While this progress has made us closer to the model of precision medicine, significant obstacles need to be overcome to use this new-found information to change the way we manage patients with pancreatic cancer.

KW - cystic neoplasms

KW - genome

KW - intraductal papillary mucinous neoplasm

KW - KRAS

KW - MCN

KW - mutations

KW - pancreatic cancer

KW - RNF43

KW - TP53

KW - whole genome sequencing

UR - http://www.scopus.com/inward/record.url?scp=85022081473&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85022081473&partnerID=8YFLogxK

U2 - 10.1097/MOG.0000000000000382

DO - 10.1097/MOG.0000000000000382

M3 - Review article

VL - 33

SP - 404

EP - 410

JO - Current Opinion in Gastroenterology

JF - Current Opinion in Gastroenterology

SN - 0267-1379

IS - 5

ER -