Genetics in lymphomagenesis

Sigurdur Y. Kristinsson, Richard Rosenquist, Ola Landgren, Lynn R. Goldin, Magnus Björkholm

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Lymphoproliferative diseases include many different disease entities with distinct cells of origin, pathologies, risk factor profiles, and prognoses. Although lymphomas are grouped traditionally into non-Hodgkin and Hodgkin lymphomas, the WHO classification today separates lymphomas into three main groups, B-cell, T-/NK-cell and Hodgkin lymphomas, where each group includes multiple subtypes. For instance, B-cell lymphomas comprise entities such as follicular lymphomas, diffuse large B-cell lymphomas, chronic lymphocytic leukemia, and lymphoplasmacytic lymphoma/Waldenström macroglobulinemia. The causes of lymphomas are mostly unknown; however, known risk factors include autoimmunity, infections, and heredity. This chapter will focus on familiality, define basic concepts in lymphomagenesis, and discuss important genetic events in specific lymphomas.

Original languageEnglish (US)
Title of host publicationNeoplastic Diseases of the Blood
PublisherSpringer New York
Pages835-847
Number of pages13
ISBN (Electronic)9781461437642
ISBN (Print)1461437636, 9781461437635
DOIs
StatePublished - Nov 1 2013
Externally publishedYes

Keywords

  • Immune system
  • Lymph nodes
  • Lymphocytes
  • Neoplastic transformation

ASJC Scopus subject areas

  • Medicine(all)

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